乙肝肝硬化患者FibroScan参数与血清炎症指标、胶原代谢指标及纤维化指标的相关性

摘要

目的:研究乙肝肝硬化患者FibroScan参数与血清炎症指标、胶原代谢指标及纤维化指标的相关性.方法:选择在本院诊断为乙肝肝硬化的患者作为研究的肝硬化组,诊断为慢性乙型病毒性肝炎且排除肝硬化的患者作为C HB组,同期在湖北医药学院附属东风医院体检的健康志愿者作为研究的对照组;进行FibroScan检查并测定肝脏弹性值(LSM),采集血清并测定炎症指标、胶原代谢指标及纤维化指标.结果:肝硬化组、CHB组的LSM 水平以及血清中sICAM1、sP-selectin、MIF、MMP2、MMP9、CatS、TGFβ1、HA、LN、PC-Ⅲ、Ⅳ-C的含量均显著高于对照组,血清中IL-21、IFN-γ、TIMP1、TIMP2的含量低于对照组;肝硬化组的 LSM 水平以及血清中 sICAM1、sP-selectin、MIF、MMP2、MMP9、CatS、TGFβ1、HA、LN、PC-Ⅲ、Ⅳ-C的含量均显著高于CHB组,血清中IL-21、IFN-γ、TIMP1、TIMP2的含量低于CHB组;肝硬化组 LSM 水平与血清中sICAM1、sP-selectin、MIF、MMP2、MMP9、CatS、TGFβ1、HA、LN、PC-Ⅲ、Ⅳ-C的含量呈正相关,与血清中IL-21、IFN-γ、TIMP1、TIMP2的含量呈负相关.结论:乙肝肝硬化患者FibroScan参数LSM对肝硬化进程中的炎症反应、胶原代谢及纤维化过程具有评估价值.%Objective:To study the correlation of FibroScan parameter with serum inflammation indexes,collagen me-tabolism indexes and fibrosis indexes in patients with hepatitis b cirrhosis.Methods:Patients who were diagnosed with hepatitis b cirrhosis in Dongfeng hospital affiliated to hubei university of medical between June 2014 and August 2017 were selected as cirrhosis group for the research,patients who were diagnosed with chronic viral hepatitis b and without liver cirrhosis were se-lected as the CHB group,and healthy volunteers who received physical examination in Dongfeng hospital affiliated to hubei uni-versity of medical during the same period were selected as the control group for the research;FibroScan was performed to de-termine the liver stiffness measurement(LSM),and serum was collected to determine the inflammation indexes,collagen me-tabolism indexes and fibrosis indexes.Results:LSM levels as well as serum sICAM 1,sP-selectin,MIF,MMP2,MMP9, CatS,TGFβ1,HA,LN,PC-Ⅲ and Ⅳ-C contents of cirrhosis group and CHB group were significantly higher than those of control group whereas serum IL-21,IFN-γ,TIMP1 and TIMP2 contents were lower than those of control group;LSM level as well as serum sICAM1,sP-selectin,MIF,MMP2,MMP9,CatS,TGFβ1,HA,LN,PC-Ⅲ and Ⅳ-C contents of cirrhosis group was significantly higher than those of CHB group whereas serum IL-21,IFN-γ,TIMP1 and TIMP2 contents lower than those of CHB group;LSM level in cirrhosis group was positively correlated with serum sICAM 1,sP-selectin,MIF,MMP2, MMP9,CatS,TGFβ1,HA,LN,PC-Ⅲ and Ⅳ-C contents,and negatively correlated with serum IL-21,IFN-γ,TIMP1 and TIMP2 contents.Conclusion:The FibroScan parameter LSM of hepatitis b cirrhosis has evaluation value for inflammatory re-sponse,collagen metabolism and fibrosis process in the course of cirrhosis.