神经节苷脂对脑室周围白质软化早产儿血浆一氧化氮合酶、白介素-1β及肿瘤坏死因子-α水平的影响

摘要

Objective:To analyze the influence on plasma inducible nitric oxide synthase (iNOS),interleukin-1β (IL-1β) and tumor necrosis factor-αr (TNF-α) levels in premature infants with periventricular leukomalacia (PVL).Methods:The clinical data of 50 premature infants with PVL in our hospital from July 2013 to July 2016 were retrospectively analyzed.The infants were divided into two groups:the control group (23 cases)in which the infants received routine treatment and rehabilitation training with addition of cerebrolysin,and the study group in which the infants treated as the control group with addition of GM-1.The response rate and plasma iNOS,IL-1β and TNF-α concentrations were compared.Results:The response rate of study group was significantly higher than that of control group (P＜ 0.05).After treatment,plasma iNOS,IL-1β and TNF-α concentrations of study group were significantly lower than those of control group (P＜0.05).Conclusions:The mechanism of GM-1 in treatment of premature infants with PVL might be related to inhibiting the release of inflammatory cytokines,reducing iNOS activity and the neurotoxicity of NO.%目的:分析神经节苷脂(GM-1)对脑室周围白质软化(PVL)早产儿血浆中诱导型一氧化氮合酶(iNOS)、白介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)的影响.方法:回顾性分析2013年7月至2016年7月陕西省渭南市妇幼保健院收治的50例PVL早产儿的临床资料,按治疗方法不同分为对照组(23例)和研究组(27例).对照组接受常规治疗及康复训练,并加用脑活素治疗;研究组在对照组治疗基础上给予GM-1治疗.比较两组的治疗有效率以及治疗前、后血浆iNOS、IL-1β和TNF-α浓度的变化.结果:研究组治疗有效率明显高于对照组(P＜0.05);治疗后两组血浆iNOS、IL-1β和TNF-α浓度均较治疗前明显降低(均P＜ 0.05),且研究组低于对照组(P＜0.05).结论:GM-1治疗PVL早产儿的机制可能与抑制炎症细胞因子释放,降低iNOS活性和减少NO参与的神经毒性损伤有关.