抗艾滋病毒的植物大环肽研究进展

摘要

Cyclotides are natural plant proteins of approximate 30 amino acids,which contain a head-to-tail cylic backbone and a cysteine knot motif. Now, more than one hundred kinds of cyclotides have been isolated. They have extensive biological activity, including antitumor, antibacterial, hemolytic activity, anti-hookworm, strengthen of uterine contraction, inhibition of trypsase, neurotensin antagonism, as well as barnacles control activity. This paper will concentrate on the recent progress of cyclotids with anti-HIV properties,which has been found in 1994.%植物大环肽是由约30个氨基酸组成的天然植物蛋白,其构成包括一条首尾相连的环化骨架以及一个特征性半胱氨酸结.目前已知的植物大环肽共有约100个,它们具有广泛的生物活性,能抗癌、抗菌、溶血、抗钩虫、促进子宫收缩、抑制胰蛋白酶,以及具有神经降压肽拮抗等能力,还能防止藤壶等海洋生物在船舶表面附着.植物大环肽的抗艾滋病病毒(HIV)特性在1994年才被发现,本文综述了近20年来关于植物大环肤类化合物抗HIV研究的进展.