酶-有机金属催化合成阳离子聚己内酯

摘要

4-Piperidine lactone (PIL ) was first synthesized by palladium carbon (Pd-C ) catalytic hydrogenolysis using 4-acid benzyl piperidine lactone (NPIL ) as the monomer . The cationic poly (4-piperdine lactone-co-caprolactone) (P (PIL-co-CL )) copolymers were further synthesized by enzyme or organometallics catalyzed ring-opening polymerization with benzyl alcohol as initiator , PIL and CL as monomers .The structure ,molecular weight and thermal properties of copolymers were characterized by Nuclear Magnetic Resonance spectroscopy (1 H-NMR) ,Fourier Transform Infrared spectroscopy (FT-IR) ,Gel Permeation Chromatography (GPC) and Differential Scanning Calorimetry (DSC) ,etc .Results showed that the cationic P(PIL-co-CL) copolymers were synthesized successfully . Compared with organometallic catalyst Sn(Oct)2 ,the immobilized enzyme Novozym 435 had the advantages of controllable polymerization and no side reaction .%首先以4-甲酸苄基哌啶内酯(N PIL)为原料,采用钯碳(Pd-C)催化加氢脱保护的方法合成了4-哌啶内酯单体(PIL);然后以苯甲醇为引发剂,分别采用酶(Novozym 435)和异辛酸亚锡(Sn(Oct)2)催化己内酯(CL)和PIL开环聚合,制备了阳离子共聚物聚(4-哌啶内酯)-co-聚己内酯(P(PIL-co-CL)).通过核磁共振氢谱(1 H-NMR)、红外光谱(FT-IR)、凝胶渗透色谱(GPC)、差示扫描量热仪(DSC)等方法对共聚物的结构组成、数均分子量以及热性能等进行了表征.结果表明:成功制备了阳离子聚合物P(PIL-co-CL),相较于有机金属催化剂Sn(Oct)2,固定化酶Novozym 435催化内酯开环聚合表现出聚合可控且无副反应的优点.