作为药物载体的壳聚糖／氧化石墨烯中空微胶囊的制备

摘要

The graphene oxide (GO)/chitosan (CS) microcapsules were prepared by using the layer by layer (LbL) self‐assembly method using SiO2 template .Oncentration ,layers and crosslinking agent were studied in this paper .Ibuprofen was used as model drug to study the drug loading and drug release properties of CS/GO microcapsules .The results show that the GO/CS microcapsules have spherical structure ,and the microcapsules are monodispersed with the diameter of 760 nm .The thickness of microcapsule wall increases with bilayers and CS concentration increased .Crosslinking process can not only improve the morphology of microcapsules ,but al‐so can slightly improve the drug loading ratio from 19% to 72% and length the drug release time from 10 to 60 h .%采用层层自组装法，以氧化硅微球为模板制备了壳聚糖（CS）／氧化石墨烯（GO）微球，去核后成功地制备了CS／G O 中空微胶囊。研究了组装次数、壳聚糖浓度和交联剂京尼平对微球及中空微胶囊形貌的影响，并以布洛芬为药物模型研究了CS／G O 中空微胶囊的载药性能及药物缓释性能。实验结果表明， CS／G O中空微胶囊具有完整的中空结构，粒径在760 n m左右。增加包裹层数和提高包裹溶液中的壳聚糖浓度都可以增加囊壁的厚度。经交联处理后， CS／G O微胶囊的囊壁更加致密和完整，其对布洛芬的载药率从19％提高至72％，释药时间从10 h延长至60 h。