XRCC1基因多态性与宫颈癌发病风险的关系

摘要

目的研究四川人群 X 线修复交叉互补基因1(XRCC1) Arg194Trp、Arg280His 多态性与宫颈癌风险的关系.方法采用病例-对照研究方法, PCR-RFLP 检测123例宫颈癌病人及性别、年龄相匹配的175例正常人群 XRCC1 Arg194Trp、Arg280His 多态性分布及与宫颈癌风险的关系.结果病例组和对照组Arg194Trp 基因型频率分布有显著性差异(P <0.05),Arg194Trp 多态性可能与个体患宫颈癌风险相关,等位基因 Trp 可能增加个体患宫颈癌的风险(OR =1.617,95%CI =1.101~2.374,P <0.05),Arg280His 在两组中分布无显著性差异(P >0.05).结论 Arg194Trp 多态性可能与宫颈癌风险相关,Arg280His 多态性与宫颈癌易感性无关.%　　The aim of this study was to elucidate the association between the polymorphism of X-rag repair cross-complementing groups 1 ( XRCC 1) Arg194Trp, Arg280His and the risk of cervical cancer in Sichuan populations. MethodsA case-control study was conducted involving 123 cervical cancer patients and 175 healthy controls. The healthy controls were matched with the cases on age and sex. The PCR-RFLP analysis was used to determine the genotypes. Results The difference of Arg280His genotypes frequency between cases and controls was not significant. Significant differences of alele frequencies were found for 194Trp between the cases and controls. Individuals with 194Trp alele showed 1.617-fold (95%CI= 1.101 ~ 2.374,P < 0.05 )increased risk of developing cervical cancer. ConclusionThe results suggest that the genetic polymorphism of Arg194Trp may be an important player in the development of cervical cancer, and it may be a possible marker for cervical cancer.