布托啡诺和舒芬太尼等效镇痛剂量用于妇科术后自控静脉镇痛的临床研究

摘要

Objective To discuss the clinical effects of combined butorphanol with sufentanil at equivalent dose on patient-controlled intravenous analgesia (PCIA) for gynecologic surgery patients. Methods Sixty gynecologic surgery patients were randomly divided into two groups equally . group S:butorphanol 5 mg+sufentanil 100μg+granisetron 9 mg;group N:butorphanol 10 mg+sufentanil 50μg+granisetron 9 mg. The two formulas were compounded respectively to 150ml analgesic solution with normal saline. The recovery times , VAS pain grades(postoperative 2 h,12 h,24 h,36 h,48 h),cases of adverse reaction on postoperative analgesia were observed and recoded . Results There were no differences on recovery times and analgesia effects(P>0.05).But N group patients had lower incidences of nausea,vomiting, dizziness, cutaneous pruritus and higher incidences of drowsiness than S group patients(P<0.05) and no urinary retention, respiratory depression of two groups patients.Conclusion Butorphanol combine with sufentanil at equivalent dose can both provide satisfactory analgesic effect in PCIA for gynecologic surgery patients and there is fewer adverse reactions in group N and the formula of group N can be one of the recommendations in PCIA.%目的：探讨布托啡诺与舒芬太尼等效镇痛剂量用于妇科手术患者自控静脉镇痛（PCIA）的临床效果。方法：60例妇科手术患者随机等分为两组，S组：布托啡诺5mg+舒芬太尼100μg+格拉斯琼9mg；N组：布托啡诺10mg+舒芬太尼50μg+格拉斯琼9mg，两组均加生理盐水配制为150ml。观察并记录苏醒时间及术后2h、12h、24h、36h、48hVAS疼痛评分、不良反应发生例数。结果：两组患者苏醒时间，镇痛效果无明显差异（P＞0.05），N组恶心、呕吐、头晕、皮肤瘙痒发生率低于S组，而嗜睡发生率高于S组（P＜0.05），两组均无呼吸抑制、尿潴留。结论：布托啡诺复合舒芬太尼等效镇痛剂量用于妇科手术患者PCIA镇痛效果均良好，但N组不良反应较少，可作为推荐PCIA方案之一。