Compositions comprising sufentanil and triazolam for operative sedation and analgesia using oral transmucosal pharmaceutical forms

摘要

A solid unit dosage form of small volume for use in sedation and operative analgesia: comprising the combination of 5 micrograms (μg, mcg) and 50 μg (mcg) of sufentanil and between 100 μg (mcg) and 500 μg ( mcg) of triazolam, where said solid pharmaceutical form is bioadhesive and is adapted to adhere to the oral mucosa until all the drug, or for the most part, has been delivered by oral administration during the period of drug delivery, where said form Solid pharmaceutical has a volume of less than 100 μL (mcL) and a mass of less than 100 mg.