颅脑损伤修复机制与载脂蛋白E基因多态性的研究进展

摘要

颅脑损伤是一种由暴力作用于头颅引起的损伤，由致伤外力作用于头部所导致的颅骨、脑膜、脑血管和脑组织的机械形变。载脂蛋白E（apolipoproteins E，ApoE）是载脂蛋白的一个重要类型，参与机体脂质代谢及胆固醇平衡的调节。近年来发现，ApoE的基因多态性与多种疾病相关，其免疫反应性与脑损伤时间有关联，神经系统的正常生长和损伤后修复都具有一定规律性。本文对ApoE的生物学特性、脑损伤后的作用机制以及在法医学中的应用前景进行综述，希望为脑创伤时间推断及其相关实验研究提供新的思路。%Brain injury is a kind of wound by violence on head, which is a mechanical distortion of skull, meninx, cerebral vascular and brain tissue due to outside force acting on head. Apolipoproteins E (ApoE ) is a major kind of apolipoprotein s, participating in the metabolismof lipid and regulating bal-ance of cholesterol. Some recent investigations showthat gene polymorphismof ApoE is associated with various kinds of diseases. Also its immunoreactivity is changed regularly with brain injury. In addition, ApoE has remarkable effect in neurological normal growth and reparative process after brain injury. This article reviews the biological characteristics and mechanismof ApoE in the repair of brain injury and application prospect in forensic medicine, which may be able to provide newideas for estimation of the brain injury time and related experimental research.