载脂蛋白E基因多态性与冠心病相关性研究进展

摘要

Coronary heart disease is a clinical multiple disease,and the main pathological basis is coronary atherosclerosis.Its pathogenesis is not yet entirely clear,which may be related to dyslipidemia,high homocysteine metabolic enzyme gene polymorphism and inflammatory reaction.Apolipoprotein E (apoE) affects all aspects of human lipid metabolism,therefore apoE gene mutation will impact the quantity,quality and phenotype of apoE,which will further affect the development of coronary heart disease.Single nucleotide polymorphisms(SNPs) in the promoter region of apoE are closely related to the occurrence of coronary heart disease.However,different studies have different results,which may be related to the difference of apoE gene SNPs of people that from different regions,nationalities and races.%冠心病是临床多发疾病,主要病理基础是冠状动脉粥样硬化,发病机制至今尚未完全清楚,可能与血脂紊乱、高同型半胱氨酸代谢酶基因多态性、炎症反应等有关.载脂蛋白E(apoE)影响着人体脂质代谢的各个环节,因此,apoE基因的突变将对apoE的数量、质量以及表型产生一定的影响,进而影响冠心病的发生发展.apoE启动子区域的单核苷酸多态性(SNPs)与冠心病发生密切相关,但不同的研究结果不同,这可能与不同地区、民族、种族等的人群apoE基因SNPs存在差异有关.