云南猝死综合征（Yunnan sudden death syndrome，YSDS）是一种每年6～9月份发生在云南省中部和西北部海拔1815～2225 m的山区、半山区，以突然发病并死亡为特征且病因不明的疾病。该病以青壮年为主，女性多于男性，傈僳族、彝族和苗族发病率较高，具有家庭聚集性，临床表现多样，病理学特点缺乏特异性，发病原因与卫生、经济条件、硒铬微量元素缺乏、柯萨奇B组病毒感染、食用蘑菇及当地特殊地质条件相关。本文综述了YSDS的流行病学特征、临床表现、病理性特点、病因研究及假说，以期对YSDS进一步研究提供线索。%Yunnan sudden death syndrome (YSDS) is an abruptly fatal disease of unknown etiology, found mostly in central or northwestern mountain area (with altitude between 1 815 and 2 225 meters ) of Yunnan province from June to September every year. It occurs mostly in young female adults, with high incidences in Lisu, Yi and Miao ethnics and high familial aggregation. The clinical manifestation of YSDS is changeful and the pathological characteristic is lack of specificity. The pathogenesis may be at-tributed to several factors including poor hygiene and lower socioeconomic conditions, lack of Selenium or Chromium, infection of Coxsackie B virus, mushroom consumption and special geological conditions. This article reviews the epidemiologic features, clinical manifestations, pathological features, etiology and hypothesis in order to provide clues for the research of YSDS.
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