Hydroxypropyl-β-cyclodextrin (HP-β-CD), containing special hydrophobic cavity, was used to include rose flavor. In this study, the average size was as major index and PDI and ζ potentia as t two auxiliary indexes to choose the optimum process parameters. The optimum conditions were determined by single-factor and he Box-Behnken design of response surface methodology and listed as follows: reaction time of 4h, electromagnetic stirring speed of l000rpm, reaction pH of 8, the mass ratio of external to internal capsule of 1. 69, the emulsifier of Tween-20, the mass ratio of emulsifier to flavor of 3. 13, solid contents of 1. 5%. Under the optimum conditions, the average size is 72. 8nm, the PDI is 0. 127, and the ζ potential is -12. 6mv. It also has a spherical shape by the transmission electron microscopy.%利用羟丙基-β-环糊精(HP-β-CD)内疏水外亲水的空腔结构对东方琥珀玫瑰香精进行包合,以平均粒径为主要指标,粒径分布系数(PDI)及ζ电位为辅助指标对胶囊进行考察.通过单因素实验找出对包合工艺影响较大的因素.在此基础上采用Box-Behnken响应面设计法优化包合工艺,得到最佳包合工艺条件:包合时间为4h,磁力搅拌转速为1 000 r/min,反应pH值为8,壁芯质量比为1.69,乳化剂为聚氧乙烯失水山梨醇单月桂酸酯(Tween-20),乳化剂香精质量比为3.13,固形物质量分数为1.5％.其平均粒径为72.8 nm,粒径分布系数为0.127,ζ电位为-12.6 mV.通过透射电镜观察发现纳米香精胶囊呈不规则的圆形.
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