单中心84例结外NK/T细胞淋巴瘤患者临床特点和预后的回顾性分析

摘要

目的:探讨结外NK/T细胞淋巴瘤患者的临床特点、治疗方案及预后的影响因素.方法:回顾性分析2006年6月至2016年6月军事医学科学院附属医院收治的结外NK/T细胞淋巴瘤患者的临床资料,探究其临床特点、疗效及预后的相关因素.结果:共收集到具有完整临床资料的结外NK/T细胞淋巴瘤病例84例,中位随访21(1-123)个月,5年总生存(OS)率和无进展生存(PFS)率分别为58.9％和52.1％.单因素分析结果显示,贫血、EBV-DNA拷贝数、LDH水平、IPI评分、ECOG评分、Ann Arbor分期、首程缓解对NK/T细胞淋巴瘤患者的OS和PFS均具有统计学意义,而化疗方案仅对PFS有统计学意义.多因素分析结果显示,首程缓解、LDH水平及ECOG评分对NK/T细胞淋巴瘤患者的的OS和PFS均有统计学意义.结论:LDH水平、ECOG评分和首程缓解是结外NK/T细胞淋巴瘤的独立预后因素.%Objective:To investigate the clinical characteristics,treatment and prognostic factors of patients with extranodal NK/T cell lymphoma.Methods:The clinical data of patients with extranodal NK/T cell lymphoma admitted in the Hospital Affiliated to the Academy of Military Medical Science from June 2006 to June 2016 were retrospectively analyzed.The clinical features,therapeutic efficacy and prognosis-related factors were clarified.Results:A total of 84 patients with extranodal NK/T cell lymphoma with complete clinical data were collected,with a median follow-up of 21 months (1-123 months),the overall survival (OS) and progression free survival (PFS) were 58.9％ and 52.1％ years,respectively.Univariate analysis showed that anemia,the copy number of EBV-DNA,LDH level,IPI score,ECOG score,Ann Arbor staging,complete remission after the initial therapy were statistically significant for both OS and PFS of the patients,and chemotherapy regimens were only statistically significant for PFS.Multivariate analysis showed that complete remission after the initial therapy,LDH level and ECOG score were statistically significant for both OS and PFS in patients with NK/T cell lymphoma.Conclusion:LDH level,ECOG score and complete remission after the initial therapy are independent prognostic factors for patients with extranodal NK/T cell lymphoma.