Objective:To analyze the relationship between GST polymorphism and childhood acute lymphoblastic leukemia (ALL) risk.Methods:The relevant references of this relationship in English or Chinese were extensively searched through PubMed,Embase,China National Knowledge Intemet (CNKI) and Wanfang Database up to August 2015 based on the inclusion and exclusion criteria.GST polymorphism-specific odd ratios (OR) with corresponding 95％ confidence intervals (CI) were calculated with the STATA statistical package.Heterogeneity across studies was assessed,and funnel plots were constructed to test the publication bias.Results:A total of 27 studies concerning the GST polymorphisms and the risk of ALL were evaluated,which included 3736 cases of childhood acute lymphoblastic leukemia and 5 549 controls.Significant summary OR of ALL were obtained for GSTM1 (OR =1.41,95％ CI =1.21 -1.65) and GSTT1 (OR =1.26,95％ CI =1.05-1.50).Subgroup analysis showed that GSTM1 variant was associated with increased susceptibility to ALL in group of Blacks,Asians,PB (Population-based controls),HB (Hospital-based controls) ≥ 100 cases'and'＜ 100 cases:Regarding GSTT1 polymorphism,significant relation with ALL risk was found in subgroup of Asians,PB and ≥ 100 cases:Conclusion:The GSTM1 and GSTT1 polymorphisms may be cerrelated with an increased risk of ALL.Further investigations are needed to confirm the conclusions.%目的:深入分析GST基因缺失与儿童ALL遗传易感性的关系.方法:基于纳入和排除标准计算机检索PubMed、Embase、中国期刊全文数据库(CNKI)和万方数据库.检索时间截止至2015年8月,检索过程中无语言限制.采用STATA 12.0软件计算OR及其95％ CI,敏感性分析验证结论的稳健性,漏斗图检测发表偏倚.结果:本研究共纳入27项病例和对照研究,包括3736例患者和5549例对照.Meta分析结果显示,GSTM1和GSTT1缺失基因型与儿童ALL之间的总OR值分别为1.41(95％ CI:1.21～1.65)和1.26(95％ CI:1.05～1.50),均较对照组显著降低,差异具有统计学意义(P=0.000,P=0.012).在亚组分析中,黑种人群、亚洲人群、PB组(来自普通人的对照)、HB组(来自医院的对照)、“≥100病例数”组和“＜100病例数”组携带GSTM1基因突变的儿童发生ALL的风险显著增高.而对于GSTT1,其多态性仅与亚洲人群、PB组和“≥100病例数”组的发病风险有相关性.结论:GSTM1和GSTT1缺失基因型可能是儿童ALL的易感因素,但该结论有待进一步证实.
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