Objective: To investigate the clinical distribution and drug resistance of four kinds of Gram-negative bacillus in Affiliated Hospital of Dali University and provide basis for clinical medicine. Methods: VITET-2 compact automated microbial analyzer was applied for bacterial identification, K-B disk diffusion method were used for drug sensitive test. Results: The drug resistance rates of four kinds of bacilli to penicillins, sulfonamides, quinolones and amoxicillin amoxicillin/clavulanic acid, gentamicin, cephalosporins, aztreonam, resistance rates were 75%, 75%, 20%, 70%, 55%, 50%, 13%, respectively. P. aeruginosa was more sensitive to ceflazidime (7.22%) and cefepime (11.86%). E. coli and K. pneurmoniae were sensitive to both carbapenem and cefoperazone/sulbactam, while P. aeruginosa were resistant to both carhapenem and cefoperazone/sulbactam, A. baumanii was sensitive to imipenem and cefoperazone/sulbactam. E. coli and P. aeruginosa were sensitive to amikacin, K. pneurmoniae was sensitive to piperacillin / tazobactam, but was resistance to others (〉14%). Conclusion: There were high drug resistences of 4 Gram-negative bacillus in affiliated hospital of Dali University, hospital should be strengthened infection control, drug monitoring and clinieal use of antimicrobial drugs, reducing the emergence of resistant or multi-drug-resistant strains.%目的：了解大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌感染现状和对常用抗菌药物耐药趋势。方法：应用VITET-2Compact全自动微生物分析仪进行细菌鉴定，K—B纸片扩散法进行药敏试验。结果：4种革兰阴性杆菌对青霉素类、磺胺类、喹诺酮类、阿莫西林／棒酸、庆大霉素、头孢类、氨曲南耐药率分别为75％、75％、20％、70％、55％、50％、13％，而铜绿假单胞杆菌对头孢他啶（7．22％）和头孢吡肟（11．86％）较为敏感。大肠埃希菌和肺炎克雷伯杆菌均对碳青霉烯类和头孢哌酮／舒巴坦敏感，铜绿假单胞杆菌对其全部耐药，鲍曼不动杆菌仅对亚胺培南、头孢哌酮／舒巴坦敏感。大肠埃希菌和铜绿假单胞杆菌对阿米卡星敏感，肺炎克雷伯杆菌对哌拉西林／他唑巴坦敏感，其它菌耐药率都超过14％。结论：大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌对常用抗生素耐药率高；医院检验科应加强细菌感染控制和耐药监测，指导临床合理使用抗生素。
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