To investigate the expressions of serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with non-Hodgkin's lymphoma (NHL) and its clinical significance. Methods:Twenty-eight cases with newly diagnosed NHL and 28 cases of healthy volunteers were involved in the study. Serum levels of IGF-1 and IGFBP-3 were determined by the method of chemical luminescence,and ratio of IGF-l/IGFBP-3 was counted. The differences were compared between two groups. Results: Serum levels of IGF-1 and IGFBP-3 were significantly lower in NHL group than those in control group (P < 0.01), but there was no difference in the ratio of IGF-I/IGFBP-3 between two groups (P > 0.05); and there were no differences in serum levels of IGF-1, IGFBP-3 and the ratio of IGF-l/IGFBP-3 among different (ypes of non-Hodgkin's lymphoma ( P > 0. 05 ). Conclusions ; Serum levels of IGF-1 and IGFBP-3 significantly decreased in patients with NHL,and might relate with NHL. The ratio of IGF-l/IGFBP-3 has no obvious correlation with NHL. Serum levels of IGF-1 and IGFBP-3 have no obvious correlation with types of NHL.%目的:探讨非霍奇金淋巴瘤(NHL)患者血清胰岛素样生长因子-1(IGF-1)及其结合蛋白-3(IGFBP-3)表达水平及其临床意义.方法:选择28例诊断初发NHL患者(淋巴瘤组)及28例健康志愿者(对照组),化学发光法测定血清IGF-1及IGFBP-3水平并计算IGF- 1/IGFBP-3值,分析组间的差异.结果:血清IGF-1及IGFBP-3水平淋巴瘤组显著低于正常对照组(均P＜0.01)；IGF-1/IGFBP-3淋巴瘤组与正常对照组差异无统计学意义(P＞0.05)；不同亚型的淋巴瘤组的血清IGF-1、IGFBP-3水平及IGF-1/IGFBP-3比值的差异均未达到统计学意义(P＞0.05).结论:N HL患者血清IGF-I及IGFBP-3水平明显降低,可能与NHL相关.IGF-1/IGFBP-3比值与NHL无明显相关性,IGF-1及IGFBP-3水平与NHL的分型无明显相关.
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