雾化吸入碱性成纤维细胞生长因子对血管性痴呆患者血管内皮生长因子的影响

摘要

目的：研究雾化吸入碱性成纤维细胞生长因子（ b-FGF ）对血管性痴呆患者血清血管内皮生长因子（ VEGF）的影响。方法：采用临床痴呆评定量表（ CDR）筛选出轻度血管性痴呆（ VD）患者60例，分成轻度VD治疗组34例，轻度VD对照组26例，另设正常对照组30例，VD对照组患者常规抗动脉硬化、抗血小板聚集及抗痴呆治疗， VD治疗组在其对照组常规治疗基础上给予bFGF 4800 AU／d加入生理盐水10 mL氧气雾化吸入，每次10 min，1次／d，连续14 d。比较2组VD患者治疗前、治疗后14、30 d血清VEGF的表达。结果：2组VD患者治疗前血清VEGF水平明显低于正常对照组，VD治疗组患者治疗后14、30 d血清VEGF水平逐渐升高，与VD对照组比较有统计学意义（P＜0．01）。结论：bFGF通过鼻黏膜进入中枢神经系统，促进VD患者血清VEGF的表达。%Objective:To study the effect of atomizing inhalation of basic fibroblast growth factor (bFGF) on serum vas-cular endothelial growth factor (VEGF) in patients with vascular dementia (VD).Methods: Sixty patients with mild VD were selected by using the clinical dementia rating scale (CDR), and were divided into VD treatment group (34 cases) and VD control group (26 cases), another 30 cases as the normal control group .Patients in VD control group received conven-tional anti atherosclerosis , anti platelet aggregation and anti dementia treatment .On the basis of conventional treatment , pa-tients in VD treatment group were given bFGF 4800 AU/d in 10mL normal saline for oxygen inhalation , 10 minutes each time, once a day, continuous for 14 days.The expression of VEGF was compared between the two groups before treatment and after treated for 14 and 30 days.Results:The expression of VEGF was lower in two VD groups before treatment than that of normal control group .The expression of VEGF increased gradually in VD treatment groups after treated for 14 and 30 days, and there was statistical difference compared to that of VD control group (P<0.01).Conclusions:bFGF might enter into the central nervous system through nasal mucosa , thus promote the expression of serum VEGF in patients with VD .