肿瘤相关巨噬细胞和巨噬细胞清除受体 1 对前列腺癌预后的预测价值:系统综述和 M eta 分析

摘要

Objective To study the roLe of tumour‐associated macrophages and the expression of macrophage scavenger receptor 1 (M SR1) in prostate cancer progression by systematic review and meta‐anaLysis . Methods We conducted a systematic search in PubM ed ,Embase and the Cochrane Library for reLevant studies .A meta‐anaLysis was performed to evaLuate the prognostic vaLue of tumour associated macrophages and MSR1 by pooLed the hazard ratio and 95% confidence intervaLs of the survivaL data . ResuLts T he resuLts showed that patients with higher density of tumour asso‐ciated macrophages had shorter overaLL survivaL ( H R＝1?57 ,95% CI :1?15‐1?98 ) ,but no signifi‐cant correLation with biochemicaL recurrence ( H R＝ 1?01 ,95% CI :0?98‐1?04 ) or recurrence‐free survivaL ( H R＝1?03 ,95% CI :0?05‐2?01).By contrast ,eLevated expression of M SR1 was signifi‐cantLy associated with better recurrence‐free survivaL ( H R＝3?26 ,95% CI :1?22‐5?29 ). ConcLu‐sions Higher density of tumour‐associated macrophages is reLated to shorter overaLL survivaL in pa‐tients with prostate cancer ,but cannot affect biochemicaL recurrence or recurrence‐free survivaL .%目的 本研究旨在通过系统综述及Meta分析研究肿瘤相关巨噬细胞(T AM s)在前列腺癌预后分析中的作用. 方法 我们在PubM ed 、Embase和 the Cochrane Library三大主要数据库对TAMs及巨噬细胞清除受体1(MSR1)与前列腺癌预后相关文献进行系统检索,筛选并提取相关数据后,合并患者生存数据的 H R及对应的95% CI并进行M eta分析. 结果 分析结果显示TAMs密度与前列腺癌患者总生存期呈负相关性(HR＝1?57 ,95% CI :1?15～1?98) ,但与患者的生化复发( H R＝1?01 ,95% CI :0?98～1?04 )和无复发生存期( H R＝1?03 ,95% CI :0?05～2?01 )无明显相关性.与此相反,前列腺癌组织 M SR1的表达上调,与患者无复发生存期呈显著正相关(HR＝3?26 ,95% CI :1?22～5?29). 结论 Meta分析结果显示更高密度的 TAMs与前列腺癌患者的更短总生存期显著相关,但是与患者的生化复发率和无复发生存期无显著相关性.