膀胱癌高表达基因 BCA7与其预后的相关性研究

摘要

Objective To evaluate the relationship between BCA7 expression and prognosis of patients with bladder cancer. Methods BCA7 protein expression was detected in 122 cases of blad-der cancer and 32 cases of paired adjacent noncancerous tissues by immunohistochemistry.Statistical analysis was performed to analyse the relationship between expression of BCA7 and clinical patholog-ical characteristics,the correlation between BCA7 and prognosis of patients. Results The BCA7 staining score in tumor tissues was significantly higher than that in the corresponding adjacent nor-mal tissues (P <0.001).In 122 specimens,32 specimens (26.2%)showed low expression of BCA7 and 90 samples (73.8%)showed high expression of BCA7.High expression of BCA7 was correlated with tumor grade and T stage (P <0.05),but has nothing to do with gender,patients'age,tumor size,the number of tumor (P >0.05).The survival time of patients with low expression of BCA7 was longer than patients with high expression of BCA7,the difference was statistically significant (P =0.003). Conclusions BCA7 protein is up-regulated in bladder cancer tissues and its expres-sion level is related to the prognosis of patients with bladder cancer.It may be an ideal prognostic marker for patients of bladder cancer.%目的分析膀胱癌高表达基因 BCA7与患者预后的关系。方法免疫组化方法检测 BCA7蛋白在122例膀胱癌组织及32例配对癌旁组织中的表达水平,应用统计学方法分析BCA7表达水平与患者的临床病理特征及预后的相关性。结果 BCA7蛋白在膀胱癌组织中染色评分明显高于配对癌旁组织(P <0.001)。122例标本中,32例(26.2%)为 BCA7低表达,90例(73.8%)为 BCA7高表达。BCA7高表达与膀胱癌组织学分级、病理分期有关(P <0.05),与患者性别、年龄、肿瘤大小、肿瘤数量无关(P 均>0.05)。BCA7低表达患者平均生存时间为(52.6±2.4)个月,高于 BCA7高表达患者的(40.9暲2.2)个月(P =0.003)。结论 BCA7蛋白在膀胱癌中高表达,其表达水平与患者预后相关,可能是一个较为理想的膀胱癌预后标志物。