地塞米松两种给药途径对控制肺癌化疗所致胃肠道反应的疗效比较

摘要

目的 探讨地塞米松不同给药途径对肺癌患者化疗后胃肠道反应的疗效.方法 80例肺癌接受化疗的患者,随机分成两组,每组40例,按地塞米松不同给药途径分为静脉注射组与穴位注射组.静脉注射组于化疗前30 min静脉推注地塞米松针5 mg,而穴位注射组化疗前30 min于双侧足三里穴位注射地塞米松针各2.5mg；两组均于化疗前15 min及化疗后4h分别静脉推注恩丹西酮注射液各8 mg以及行护胃、补液等综合治疗.记录两组化疗后第1、2、3d的恶心、呕吐情况.结果第1d两组恶心、呕吐的反应差异无统计学意义(P＞0.05),第2、3d两者的恶心、呕吐的反应差异均有统计学意义(P＜0.05),穴位注射组恶心、呕吐的反应更少；完全控制率分别为40％与50％、17.5％与37.5％、40％与70％,第1d两组完全控制率差异无统计学意义(P＞0.05),第2、3d两组的完全控制率差异均有统计学意义(均P＜0.05),穴位注射组完全控制率更高.结论地塞米松穴位注射比静脉注射对控制肺癌患者化疗后的胃肠道反应疗效较好,值得临床推广.%Objective To observe the efficacy of lung cancer chemotherapy-induced gastrointestinal reaction by different dosing routes of dexamethasone. Methods 80 cases of lung cancer patients receiving chemotherapy were randomly divided into two groups of 40 cases, according to the different routes of administration. Intravenous injection group was injected dexamethasone 5 mg at 30 minutes before chemotherapy, while acupoint injection group was respectively injected dexamethasone 2. 5 mg on bilateral Zusanli point at 30 minutes before chemotherapy. Both groups accepted Ondansetron Hydrochloride injection of 8mg and at 15 minutes before chemotherapy and 4 hours after chemotherapy, as well as comprehensive treatment. The nausea and vomiting were recorded on the first, second and third day after chemotherapy. Results The response rate of gastrointestinal nausea and vomiting between the two groups on the first day was no significant difference ( P >0. 05), while those were statistically significant (both P <0. 05), on the second and third day. The response rate of acupoint injection group was lower than that of intravenous injection group. The complete control rates of two groups on three days respectively were 40% and 50%, 17. 5% and 37. 5%, 40% and 70%. The complete control rate of gastrointestinal nausea and vomiting between the two groups on the first day was no significant difference ( P >0. 05), while those were statistically significant (both P <0. 05) on the second and third day. The complete control rate of acupoint injection group was higher than that of Intravenous injection group. Conclusion Controlling the lung cancer chemotherapy-induced gastrointestinal reaction of acupoint injection was more effective than that of Intravenous injection.