结直肠癌患者血清组织基质金属蛋白酶抑制剂-1水平及其临床意义

摘要

Objective To detect the serum level of tissue inhibitor of metalloproteinase - 1 ( TIMP - 1) in patients with colorectal cancer( CRC) and explore its clinical significance. Methods Serum levels of TIMP - 1 were measured using ELISA in 64 patients with CRC confirmed by pathology ,40 patients with benign colorectal diseases and 40 healthy individuals. The association between serum levels of TIMP - 1 and clinicopathologic features of CRC was analyzed. Results The serum TIMP - 1 level in CRC patients was significantly higher than that in benign colorectal disease patients and the healthy individuals (P <0.001). The serum TIMP - 1 level was not significantly associated with sex,age,tumor size or lymph node metastasis(P >0.05 for all comparisons); An elevated serum TIMP - 1 level was found in patients with advanced diseases stage, distant metastasis and poorly differentiated histopathological tumor grade (P <0.05 for all comparisons). Conclusion Serum TIMP - 1 level is correlated with clinical stage,distant metastasis and degree of cell differentiation,and it can probably be recognized as a biomarker of prognosis in CRC patients.%目的 检测结直肠癌患者血清组织基质金属蛋白酶抑制剂-1 (TIMP -1)水平并探讨其临床意义.方法 采用酶联免疫吸附分析法(ELISA)对64例经病理证实的术前结直肠癌患者、40例结直肠良性病患者和40例健康体检者血清TIMP -1水平进行检测.结果 结直肠癌患者血清TIMP -1水平明显高于结直肠良性病患者和健康体检者(P＜0.001)；结直肠癌患者血清TIMP -1水平与性别、年龄、肿瘤大小及淋巴结转移不相关(P＞0.05),与肿瘤分期、远处转移有关(P＜0.05),肿瘤细胞分化程度低的患者血清TIMP -1水平高于细胞分化程度高的患者(P＜0.05).结论 血清TIMP -1水平与结直肠癌的肿瘤分期、远处转移及分化程度有关,可能是一个判断结直肠癌预后的生物学指标.