p53蛋白表达与三阴性乳腺癌及其预后相关性的Meta分析

摘要

Objective To evaluate the expression of p53 in triple negative breast cancer( TNBC) and its impact on the prognosis of TNBC systematically. Methods Documents published on PubMed, Medline,CNKI,CNKI,Wanfang data,and VIP data were screened for relative researches. Two reviewers filtered,extracted and assessed the literatures according to the inclusion criteria and exclusion criteria. The meta analysis was conducted by using RevMan5. 0 software. Result A total 13 trails were included,con-taining 11 Chinese documents and 2 English documents. The meta analysis showed that p53 is significantly expressed in TNBC[OR=2. 02,95%CI(1. 28,3. 19)]. TNBC patients with positive p53 expression had higher rates in lymph node metastasis[OR=2. 02,95%CI(1. 28,3. 19)],recurrence[OR=3. 39,95%CI(1.45,7. 90)],metastasis[OR =2. 65(1. 36,5. 18)],disease-free survival[OR =0. 29(0. 18, 0. 47)]and overall survival[OR=0. 29(0. 18,0. 47)]than patients with negative p53 expression. Con-clusion p53 is overexpressed in TNBC,which plays a certain role in guiding the clinical prognosis of TN-BC. It can be regarded as an independent factor to evaluate the prognosis of TNBC,and a therapeutic tar-get in further studies.%目的：系统评价p53在三阴性乳腺癌中的表达情况以及其阳性表达对三阴性乳腺癌患者的预后因素的影响。方法通过PubMed、Medline、CNKI、WanFang data、VIP数据库检索国内外已公开发表的相关文献资料。由2位研究者按照纳入与排除标准独立筛选文献、提取资料和质量评价后，采用RevMan 5.0软件进行Meta分析。结果纳入文献13篇，其中中文文献11篇，英文文献2篇。Meta分析结果显示：p53蛋白在三阴性乳腺癌患者中的表达较高，具有显著的统计学意义[ OR＝2.02，95%CI（1.28，3.19）]。三阴性乳腺癌中p53阳性表达组的淋巴结转移率和复发率高于阴性组，无病生存率和总生存率低于阴性组，且结果均有统计学意义。结论 p53在三阴性乳腺癌中高表达，且具有一定的临床预后指导意义，其可以作为评估三阴性乳腺癌预后的一个独立因素，且在以后的研究中，有可能可作为指导三阴性乳腺癌靶向治疗的一个靶点。