信号传导与转录激活因子3在乳腺癌中的表达及其与人基质金属蛋白酶2、9的关系研究

摘要

Objective To observe the expression of STAT3(signal transducer and activator of transcription 3,STAT3)in breast cancer and explore the relationship between the expression and clinical features.Methods The expression of STAT3,IL-6(interleukin,IL-6),MMP(matrix metalloproteinase,MMP)-2 and MMP-9 in 23 cases of breast cancer were observed by immunohistochemistry(EnVision)and positive rates were calculated.Chi Square and Spearman correlation coefficients were used to further analyze the correlation between STAT3 expression and clinical pathological features.Results The expression of STAT3 in invasive carcinoma was higher than that in non-invasive carcinoma.11 cases of IL-6,10 cases of MMP-2,9 cases of MMP-9 were positive in 23 cases of breast cancer,positive rate were 47.83%,43.48% and 39.13% respectively.There was a significant difference between STAT3 positive expression and invasive breast cancer(χ2=7.738,P<0.05),and there was a significant positive correlation between them(r=0.161,P<0.05).There was no significant correlation between STAT3 positive expression and IL-6 positive expression(r=0.032,P>0.05),while significant correlations were with MMP-2(r=0.649,P<0.05)and MMP-9(r=0.537,P<0.05)respectively.Conclusion STAT3 is closely related to invasion of breast cancer,which may be to controll the invasion and metastasis of breast cancer by regulating the expression of MMP-2 and MMP-9.%目的 观察乳腺癌组织中信号传导与转录激活因子3(signal transducer and activator of transcription 3,STAT3)的表达,分析其与患者临床特征的关系.方法 应用免疫组织化学法(EnVision)检测23例乳腺癌患者癌组织中STAT3、白细胞介素-6(interleukin,IL-6)、人基质金属蛋白酶(matrix metalloproteinase,MMP)-2和MMP-9的表达情况,并分析其与患者临床病理特征的关系.结果 浸润性癌组织中STAT3表达高于非浸润性癌.23例乳腺癌组织中IL-6表达阳性11例,阳性率47.83%;MMP-2阳性10例,阳性率43.48%;MMP-9阳性9例,阳性率39.13%;STAT3阳性表达与浸润型乳腺癌有统计学差异(χ2=7.738,P<0.05),两者呈正相关(r=0.161,P<0.05);STAT3阳性表达与IL-6阳性表达无相关性(r=0.032,P>0.05),与MMP-9(r=0.537,P<0.05)和MMP-2(r=0.649,P<0.05)阳性表达呈正相关.结论 STAT3与乳腺癌的浸润侵袭有关,其可能是通过调节MMP-2和MMP-9的表达控制乳腺癌的侵袭和转移.