目的:评价0.1％他克莫司治疗糜烂型口腔扁平苔癣(OLP)的疗效和安全性.方法:根据相关标准纳入68例糜烂型OLP患者,随机分成两组,双盲法下分别外用0.1％他克莫司和0.05％丙酸氯倍他索治疗,观察和比较两组的总有效率、不良反应发生率及停药6个月后复发率.结果:他克莫司组和丙酸氯倍他索组总有效率分别为97.1％、93.9％,两组间差异无统计学意义(P＞0.05)；两组间复发率分别为6.5％、10.3％,差异无统计学意义(P＞0.05)；两组的局部不良反应发生率均较低且无显著差异(P＞0.05).结论:局部外用他克莫司在改善OLP患者体征(病损面积)和症状(疼痛)方面效果显著;他克莫司治疗OLP的总有效率、治疗期间局部不良反应发生率及停药后复发率均与糖皮质激素相当.%Objective: To evaluate the treatment efficacy and safety of tacrolimus in oral clichen planus (OLP) compared with glucocorticoid. Method: 68 consecutive patients with oral lesions consistent clinically and histologically with OLP were recruited.The patients were divided into 2 groups to receive clobetasol 0.05 % or tacrolimus 0.1 % ointment and were treated for 4 weeks. Result: The Total effective rate, side-effect incidence and recurrence rates did not differ between the tacrolimus and clobetasol treatment groups (P >0.05) . separately. Conclusion: Tacrolimus could effectively both alleviate pain and reduce lesion area of patient with OPL. Total effective rate or side—effect incidence during treatment or OPL recurrence rate after stopping treatment of tacrolimus is the same with that of glucocorticoid. Further high—quality, multi—center RCTs with standard clinical evaluation are required to provide more reliable evidence.
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