代谢综合征患者中心动脉反射波增强指数与胰岛素抵抗的关系

摘要

[Objective] To explore the relationship between augmentation index(AIx) of echo of central artery and insulin resistance(IR) in metabolic syndrome(MS) patients. [Methods] The pulse wave analyzer was used to record the pulse wave of radial artery which was exchanged to corresponding pulse wave of central artery by computer. AIx of 96 MS patients was measured. Fasting plasma glucose(FPG), total cholesterol (TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol (LDL-C) and fasting insulin(FINS) were determined. According to the AIx(40％W), all MS cases were divided into two groups. Comparative analysis was done. [Results]Correlation analysis showed that there was positive correlation between AIx and HOMA-IR, TC, TG and LDL-C in MS patients( P = 0. 005, 0. 029, 0. 002, 0. 013). IR increased with the increasing of the AIx. [Conclusion] AIx in MS patients can be helpful for exactly evaluating the degree of IR.%[目的]探讨代谢综合征(MS)患者中心动脉反射波增强指数(Augmentation Index,AIx)与胰岛素抵抗(Insulin Resistance,IR)之间的关系.[方法]采用脉搏波分析仪记录桡动脉脉搏波,经计算机自动转换为相应的中心动脉脉搏波,测定96例MS患者的AIx,并测空腹血糖(FPG)、空腹胰岛素浓度(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C).将全部MS患者按AIx 40%为界分为两组,并进行比较分析.[结果]相关分析显示,MS患者AIx与胰岛素抵抗指数(HOMA-IR)、TC、TG、LDL-C呈正相关(P分别为0.005、0.029、0.002、0.013),随着AIx的增加IR程度也增加.[结论]MS患者AIx值可以帮助临床医师较准确的评估IR程度的高低.