COPD患者机械通气早期肠内营养时血浆胃动素、二胺氧化酶浓度变化及其意义

摘要

[Objective]To explore the changes of plasma concentration of motilin (MTL) and diamine oxi dase(D∧O) concentration in chronic obstructive pulmonary disease(COrD) patients who received early enteral nutrition(EN) support. [Methods]Fifty three COrD patients with mechanical ventilation were treated with EN. The concentrations of plasma MTL and D∧O at before, 24h and 48h after mechanical ventilation were measured. [Results] Of the 53 patients, 39 patients tolerated EN treatment while 14 patients did not tolerate.The concentrations of plasma MTL and D∧O at before, 24h and 48h after mechanical ventilation in patients who did not tolerated EN treatment were higher than those in patients who tolerated EN treatment ( P ＜0.05). [Conclusion]The concentrations of plasma MTL and D∧O can be used as indicators for evaluating the EN tolerance before EN treatment in COrD patients with mechanical ventilation.%[目的]探讨慢性阻塞性肺疾病(COPD)患者机械通气早期进行肠内营养支持(EN)时血浆胃动素(MTL)、二胺氧化酶(DAO)浓度的变化及其意义.[方法]给予53例COPD机械通气患者EN治疗,并检测其机械通气前及机械通气后24 h、48 h的MTL、DAO水平.[结果]53例患者中出现EN耐受患者39例,不耐受患者14例,不耐受EN患者机械通气前及机械通气后24 h、48 h的MTL、DAO水平均高于耐受患者(P<0.05).[结论]血浆MTL、DAO水平可以作为对COPD机械通气患者进行早期肠内营养前耐受性评价的指标.