2型糖尿病患者颈动脉粥样硬化与亚临床炎症因子的关系

摘要

[Objective] To observe the association between carotid atherosclerosis (AS) and chronic sub-clinical inflammatory factors in patients with type 2 diabetes mellitus(T2DM). fMethodsl Bilateral carotid in-tima media thickness(IMT) of 136 T2DM patients was measured. According to the result of ultrasonic examination, all patients were divided into AS group(n=51) and control group(group C, n=85). Fasting plasma glucose(FBG) , fasting plasma insulin ( FINS) , glycosylated hemoglobin( HbA1c) , triglyceride(TG) , total cholesterol(TC) , low density lipoprotein (LDL) , high sensitivity C-reaction protein (hsCRP) , white blood count(WBC) of peripheral blood, body mass index(BMI) and insulin resistance index(HOMA-IR) were compared between two groups. [Results]Compared with group C, BMI, HbA1c, HOMA-IR, TG, LDL, hsCRP and WBC in group AS increased, and there were significant differences(P<0. 05 or P<0. 01). Correlation a-nalysis showed that IMT was positively related with BMI, HbA1c, HOMA-IR, LDL, hsCRP and WBC. [Conclusion] Chronic subclinical inflammation may be involved in the occurrence and development of macroan-giopathy in T2DM. The levels of inflammatory factors can provide the evidence for predicting and assessing the condition of the disease.%[目的]观察2型糖尿病(T2DM)患者颈动脉粥样硬化与慢性亚临床炎症因子的关系,探讨炎症反应对糖尿病大血管病变的影响.[方法]检测136例T2DM患者双侧颈总动脉内-中膜厚度(IMT),根据超声检查结果,分为颈动脉粥样硬化组(A组,51例)和对照组(C组,85例),比较两组空腹血糖(FBG)、空腹胰岛素(FINS)、糖化血红蛋白(HbAlc)、甘油三酯(TG)、总胆固醇(TC),低密度脂蛋白(LDL)、超敏C反应蛋白(hsCRP)、外周血白细胞(WBC)计数及体重指数(BMI)、胰岛素抵抗指数(HOMA-IR).[结果]A组与C组比较BMI、HbAlc、HOMA-IR、TG、LDL以及hsCRP,WBC均升高,且差异均具有显著性(P＜0.05或P＜0.01).相关分析显示IMT与BMI、HbAlc、HOMA-IR、LDL、hsCRP、WBC呈正相关.[结论]慢性亚临床炎症参与T2DM大血管病变的发生及发展,炎症因子水平可为预测和评估病情提供依据.