[Objective] To observe the efficacy of two kinds of intensive insulin therapy(three short and a long) such as the injection of aspart 30R three times a day or the injection of aspart R before the meal combined with Lantus at bedtime for the treatment of newly diagnosed type 2 diabetes mellitus. [Methods] Totally 68 patients with newly diagnosed type 2 diabetes mellitus in our department from Feb. 2009 to Feb. 2010 were randomly divided into group A and group B. Group A received subcutaneous injection of pre meal aspart 30R and group B group received subcutaneous injection of pre meal aspart R plus Lantus at bedtime. After dis charge, the treatment continued for 12 weeks. Blood glucose, glycosylated hemoglobin(HbAlc) , the average daily insulin dose and hypoglycemia at 5 time points (fasting and 2h after 3 meals, bedtime) were observed. [Results] Compared with before insulin therapy, blood glucose and HbAlc at each time point decreased after insulin therapy( P <0. 05). Two kinds of intensive insulin therapy were effective, but the insulin dosage, the time of target blood glucose, hospital stay and the incidence of hypoglycemia in group A were lower than those in group B, and there were significant differences( P <0. 05). [Conclusion] For newly diagnosed type 2 dia betic patients, the injection of aspart 30R three times a day is a fast, effective and safe method of intensive in sulin therapy.%[目的]观察诺和锐30R三餐前皮下注射与诺和锐R三餐前皮下注射加睡前注射来得时在初诊的2型糖尿病患者的疗效,胰岛素用量和低血糖风险.[方法]将本科2009年2月至2010年2月期间68例初诊的2型糖尿病住院患者随机分成A、B组,A组使用诺和锐30R三餐前皮下注射;B组使用诺和锐R三餐前皮下注射加睡前注射来得时,出院后继续治疗,为期12周.观察两组患者5个时点(空腹及三餐后2 h,睡前)的血糖、糖化血红蛋白(HbA1c),每天胰岛素平均用量及低血糖事件的差异.[结果]两组患者经过胰岛素治疗后各时点血糖及HbA1c均较治疗前明显下降(P<0.05),A和B两组胰岛素强化治疗方法均有效,但A组胰岛素用量、血糖达标时间、住院天数、低血糖发生率均低于B组、有统计学差异(P<0.05).[结论]对于初诊2型糖尿病患者,每天3次餐前注射诺和锐30R是一种快速、有效、安全的强化治疗方法.
展开▼
