肺腺癌患者表皮生长因子受体酪氨酸激酶结构域突变与放射敏感性的关系

摘要

[Obj ective]To explore the relationship between epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD)mutation and radiosensitivity in patients with lung adenocarcinoma.[Methods]A total of 3 6 lung adeno-carcinoma patients with EGFR-TKD mutation were selected as the observation group.A total of 24 patients without EG-FR-TKD mutation were selected as the control group.Three-dimensional conformal radiotherapy was performed in prima-ry lung lesions of patients in 2 groups.Chest CT reexamination was performed 1 month after radiotherapy and used to e-valuate the short-term efficacy.[Results]All patients completed the treatment smoothly.In the observation group,1 0 patients were complete remission(CR),and 24 patients were partial remission(PR),and 2 patients were stable,and no one was developed,and the short-term total effective rate(CR+PR)was 94.4%.In the control group,7 patients were complete remission(CR),and 1 0 patients were partial remission(PR),and 6 patients were stable,and 1 patient was de-veloped,and the total short-term effective rate was 70.8%.There was significant difference in the short-term efficacy be-tween two groups(P<0.05).[Conclusion]Lung adenocarcinoma patients with EGFR-TKD mutation have better short-term efficacy.It suggests that EGFR-TKD mutation is an important indicator of predicting radiosensitivity.%【目的】探讨肺腺癌患者表皮生长因子受体酪氨酸激酶结构域（EGFR-TKD）突变与放射敏感性的关系。【方法】将36例肺腺癌并 EGFR-TKD突变者列为观察组，24例无突变者列为对照组。对两组患者肺部原发病灶均采用三维适形放射治疗，放疗结束后1个月复查胸部 CT评价近期疗效。【结果】全部患者均顺利完成治疗，观察组完全缓解（CR）10例，部分缓解（PR）24例，稳定2例，进展0例，近期总有效率（CR＋PR）94．4％。对照组CR 7例，PR 10例，稳定6例，进展1例，近期总有效率70．8％。两组患者近期有效率比较差异有显著性（P＜0．05）。【结论】肺腺癌 EGFR-TKD突变患者的近期放疗效果好，提示 EGFR-TKD突变是预测放射敏感性的重要指标。