大肠癌中c-Jun激活区结合蛋白1（Jab1）的表达及其意义

摘要

[Objective]To explore the expression and significance of c‐Jun activation domain binding protein 1 (Jab1) in patients with colorectal cancer .[Methods]From January 2010 to January 2014 ,98 samples of colorectal cancer tissues and adjacent normal tissues were collected and analyzed by immunohistochemistry (SP method) to de‐tect the expression of Jab1 .[Results]Jab1 had a positive expression rate of 96 .9% (95/98) in colorectal cancer tissues versus 17 .3% (17/98) in corresponding adjacent tissues .And the inter‐group differences were statistically significant ( P<0 .05) .Jab1 expression was significantly correlated with tumor cell differentiation ,depth of invasion ,TNM stage and lymph node metastasis ( P<0 .05) .However ,gender ,age or tumor size had no significant correlation ( P>0 .05) .The 1 ,3 ,5‐year survival rates of JAB1‐positive patients were 81 .0% ,49 .6% and 31 .0% versus 100 .0% ,87 .5% and 75 .0% of JAB1‐negative ones .And the differences were statistically significant ( P<0 .05) .[Conclusion]Jab1 is involved in the occurrence of colorectal cancer ,invasion and metastasis .And its expression deter‐mines the prognosis of patients with colorectal cancer .%目的探讨大肠癌中c‐Jun激活区结合蛋白1（Jab1）的表达及其临床病理指标和预后的关系。方法收集98例大肠癌组织（大肠癌组）和相应癌旁组织标本（对照组），采用免疫组织化学方法检测两组Jab1的表达并比较。结果Jab1在大肠癌组中的阳性表达率为96．9％（95／98），显著高于对照组17．3％（17／98），其差异有统计学意义（ P ＜0．05）；Jab1阳性表达与肿瘤细胞分化程度、浸润深度、TNM 分期和淋巴结转移显著相关（ P ＜0．05）；与患者性别、年龄、肿瘤大小无显著相关（ P ＞0．05）；JAB1阳性表达患者1年、3年、5年生存率分别为81．0％、49．6％、31．0％；阴性表达患者1年、3年、5年生存率分别为100．0％、87．5％、75．0％，其差异具有统计学意义（ P＜0．05）。结论 Jab1可能参与了大肠癌的发生、浸润及转移；根据Jab1的表达可判断大肠癌患者的预后。