成人免疫性血小板减少症骨髓巨核细胞数变化与疗效的关系

摘要

[目的]探讨成人免疫性血小板减少症(IT P)患者骨髓巨核细胞数变化与疗效的关系.[方法]本院收治的成人IT P患者140例,在治疗前均行骨髓巨核细胞涂片检查,将巨核细胞数<7个/4.5 cm2的归为Ⅰ组,巨核细胞数为7~35个/cm2的归为Ⅱ组,巨核细胞数>35个/cm2的归为Ⅲ组,三组患者均采用相同的方案进行治疗,比较三组患者的疗效.[结果]Ⅰ组总有效率为25.00%(4/16),Ⅱ组为76.47%(26/34),Ⅲ组为93.33%(84/90),Ⅲ组总有效率明显高于Ⅱ组和Ⅰ组,Ⅱ组明显高于Ⅰ 组,且各组之间比较差异均有显著性(P < 0.01).[结论]成人IT P患者的骨髓巨核细胞数变化对治疗效果有很大的影响,骨髓巨核细胞数增值有利于提高疗效.%[Objective]To explore the relationship between bone marrow megakaryocyte number and corre-sponding therapeutic effect in patients with adult immune thrombocytopenia(ITP).[Methods]A total of 140 adult ITP patients treated in our hospital were selected in this study.Before treatment,all of the patients received bone marrow megakaryocyte smears.According to the number of bone marrow megakaryocyte,patients were divided into three groups:group Ⅰ < 7/4.5 cm2,group Ⅱ 7~35/cm2,and group Ⅲ >35/cm2.All patients of the three groups received the same treatment,and the therapeutic effect were compared among them.[Results]The total ef-fective rate was 25.00%(4/16)in group I,76.47%(26/34)in group Ⅱ,and 93.33%(84/90)in group Ⅲ.The total effective rate of group Ⅲ was significantly higher than that of group Ⅰ and group Ⅱ;The rate of group Ⅱwas significantly higher than that of group Ⅰ.The difference between groups was statistically significant(P <0.01).[Conclusion]The changes in the number of bone marrow megakaryocytes in adult ITP patients have a great influence on the therapeutic effect.The increase in the number of bone marrow megakaryocytes is beneficial to im-prove the therapeutic effect.