Objective To explore the effective treatment for idiopathic pulmonary fibrosis. Methods Sixty-five cases of idiopathic pulmonary fibrosis were divided into control group, the first treatment group, and the second treatment group. They received routine prednisone, prednisone added with cyclophosphamide, and prednisone with high-dose N-acetylcysteine respectively, and the changes of clinical manifestations, chest imaging and lung functions before and after the treatment were compared. Results Clinical manifestations for patients in the control group and the first treatment group were nearly the same before and after the treatment, while patients in the second treatment group recovered significantly much better than that in the control group and the first treatment group. Concliusion Prednisone with high-dose of N-acetylcysteine is an effective treatment for idiopathic pulmonary fibrosis.%目的 探讨特发性肺间质纤维化的临床有效治疗方法.方法 将65例特发性肺间质纤维化患者分为治疗组1、治疗组2和对照组三组.对照组给予常规强的松治疗;治疗组1给予强的松加环磷酰胺治疗;治疗组2给予强的松加大剂量N-乙酰半胱氨酸治疗.观察并比较患者治疗前后临床症状体征、胸部影像学及肺功能的变化.结果 治疗前各组间具有可比性.治疗后,治疗组1与对照组的疗效无明显差异;而治疗组2的疗效则明显好于治疗组1及对照组.结论 强的松联合大剂量N-乙酰半胱氨酸是临床治疗特发性肺间质纤维化的有效手段.
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