慢性阻塞性肺疾病并2型糖尿病患者的免疫功能分析

摘要

Objective To investigate the immunoloical function of patients with chronic obstructive pulmonarydisease (COPD)complicated type Ⅱ diabetes(T2DM). Methods 30 patients with COPDcomplicated T2DM ,30 patients with simple COPD and 20 individuals served as control. Levels of IgA,lgM and lgG were determined with rate nephelometry method,the CD3 + ,CD4 + ,CD8 + ,CD4 +/CD8 + in peripheral blood were measured by flow cytometry. Then the results were anulyzedl. Results The COPD complicated T2DM group had a more decreased IgA, IgM, IgG,CD4 + level,CD4 +/CD8 + ratio and more increased CD8 + level,compaed with simple COPD control and the control( P ＜ 0. 05 ). Conclusion Patient swith COPD complicated T2DM have a bad immune functionl The immune treatment may improve the prognosis.%目的 观察慢性阻塞性肺疾病(COPD)并2型糖尿病(T2DM)患者的免疫功能,探讨其临床意义.方法 选择COPD稳定期的患者60例,其中COPD合并T2DM患者30例、单纯COPD患者30例,健康对照组20例.检测外周血IgA、IgG、CD3+、CD4+、CD8+及CD4+/CD8+水平,并进行统计学分析.结果 COPD患者与健康对照组相比,外周血CD3+、CD4+、CD4+/CD8+、IgA、IgG、IgM均低,CD8+水平较高,差异有统计学意义(P<0.05);其中COPD合并T2DM患者与单纯COPD组相比,差异有统计学意义(P<0.05).结论 COPD并T2DM患者稳定期存在免疫功能异常,给予免疫干预治疗可能会减少COPD患者急性加重次数,改善预后.