Objective To probe into the therapeutic efficacy and safety of 3 therapeutic schemes in the treatment of antituberculo-sis drug-induced hepatotoxicity in HIV/TB patients. Methods A total of 126 patients were randomly into three groups, including Group A ( deoxidized glutathione by oral administration ), Group B ( compound glycyrrhizin by oral administration ) and Group C ( deoxidized gluta-thione and compound glycyrrhizin by intravenous injection ). The clinical effects of the three groups were observed and compared. Results The effective rates for the 3 treatment schemes were respectively 92. 9% , 90. 5% and 97. 6% , without significant differences between the groups( P >0. 05 ). The cure rate were respectively 52. 4% , 45. 2% and 71. 4% , with significant differences between the groups( P < 0. 05 ). The incidences for adverse effects were respectively 31 % , 23. 8% and 47. 7% , without significant differences between the groups ( P > 0. 05 ). There was no significant difference in the effective rates and the adverse effect rates produced by three therapeutic schemes when they were used to treat the antituberculosis drug-induced hepatotoxicity in HIV/TB patients, while there was a significant difference in the cure rate. Conclusion Group C had the best therapeutic effect.%目的 探讨3种不同治疗方案用于治疗HIV/TB患者抗结核药物性肝损伤的有效性及安全性.方法 将126例患者随机分成3组,A组(还原型谷胱甘肽口服)、B组(复方甘草酸苷口服),C组(还原型谷胱甘肽+复方甘草酸苷静滴),观察比较疗效.结果 3种药物治疗方案有效率分别为92.9% 、90.5% 、97.6%(P>0.05),治愈率分别为52.4%、45.2%、71.4%(P<0.05),发生不良反应率分别为31% 23.8% 47.7%(P>0.05);三种方案治疗HIV/TB患者抗结核药物性肝损伤在有效率和不良反应发生率方面无显著差异,但在治愈率上三组有显著差异.结论 C组临床疗效最好.
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