目的 探讨噻托溴铵联合沙美特罗氟替卡松对重度支气管哮喘的临床疗效,提高患者的生活质量.方法 对照组给予大剂量沙美特罗氟替卡松粉吸入剂,观察组给予吸人噻托溴铵粉吸入剂联合中等剂量沙美特罗氟替卡松粉吸入剂.结果 观察组治疗总有效率为88.0%,对照组治疗总有效率为62.0%,两组对比差异显著,P<0.05.治疗后两组的肺功能较治疗前均有改善,差异有统计学意义,P<0.05;且观察组较对照组改善更明显,差异有统计学意义,P<0.05.结论 噻托溴铵联合沙美特罗氟替卡松改善患者生活质量,减少急性加重发作的次数,值得临床推广.%Objective To explore the clinical effect of tiotropium bromide combined with salmeterol and fluticasone in the treatment of patients with severe bronchial asthma. Methods The control group was given high doses of salmeterol and fluticasone powder inhaler, and the observation group was treated with tiotropium powder combined with moderate-dose of salmeterol and fluticasone powder. Results The total effective rate was 88% in the observation group and 62% in the control group with significant difference ( P <0. 05 ). The lung functions of the two groups were obviously improved after the treatment, and the improvement was more pronounced in the observation group than in the control group ( P < 0. 05 ). Conclusion Tiotropium bromide combined with salmeterol and fluticasone can improve the quality of life and reduce the incidence of acute exacerbations in the treatment of patients with severe bronchial asthma, which is worthy of widely clinical application.
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