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PHARMACEUTICAL INHALED MEDICATION FOR TREATMENT OF BRONCHIAL ASTHMA AND CHRONIC OBSTRUCTIVE LUNG DISEASE, CONTAINING MICRONISED TIOTROPIUM BROMIDE AS ACTIVE SUBSTANCE AND METHOD OF ITS PRODUCTION
PHARMACEUTICAL INHALED MEDICATION FOR TREATMENT OF BRONCHIAL ASTHMA AND CHRONIC OBSTRUCTIVE LUNG DISEASE, CONTAINING MICRONISED TIOTROPIUM BROMIDE AS ACTIVE SUBSTANCE AND METHOD OF ITS PRODUCTION
FIELD: medicine, pharmaceutics.;SUBSTANCE: invention relates to medicine and the pharmaceutical industry and describes a pharmaceutical inhaled medication for treatment of bronchial asthma and chronic obstructive lung disease, containing micronised tiotropium bromide as an active substance, and which contains as a carrier lactose with the average particle size of 120-200 mcm, sodium benzoate, sieved with a bulk density within the range of 0.30-0.50 g/cm3 and sodium benzoate micronised with the average particle size of 0.5-10 mcm with a specified content of components per a dose of medication.;EFFECT: invention provides higher percent of a respirable fraction of the active substance and, therefore, higher pharmacological activity.;3 cl, 10 ex
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机译:发明领域本发明涉及医学和制药工业,并且描述了一种用于治疗支气管哮喘和慢性阻塞性肺疾病的药物吸入药物,其包含微粉化的噻托溴铵作为活性物质,并且包含作为载体的乳糖平均粒径为120-200 mcm的苯甲酸钠筛分,其堆积密度在0.30-0.50 g / cm 3 Sup>范围内,微粉化的苯甲酸钠,平均粒径为0.5-10 mcm,每剂量药物指定成分含量。效果:本发明可提供更高百分比的活性物质可呼吸部分,因此具有更高的药理活性。3 cl,10 ex
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