Objective To compare the rliniral effect and safety oi cyclophosphate combined with milrinone vs digitalis in the treatment oi patients with chronic pulmonary heart disease. Methods 108 patients were all given conventional treatment and then were randomly and evenly divided into two groups. The treatment group was treated with cyclophosphate combined with milrinone additionally, and the control group was treated with digitalis additionally. 12 days were a treatment course. Results The total effective rates were 94. 49c and 66. 69c respectively in the treatment group and in the control group ( P < 0. 01 ). The improvement oi he ait junction, lung junction, blood gas indexes and BNP was more pronounced in the treatment group than in the control group ( P < 0. 01 ). There was no sig-niiicant difference oi heart rate and blood pressure between the two groups ( P > 0. 05 ). The adverse effects in the treatment group included palpitation, diaphoresis and headache which disappeared by reducing the infusion rate, while the major adverse effects in the control group was arrhythmia which often ended up with withdraw oi the drug. Conclusion The combination oi cyclophosphate and milrinone has a better curative effect with less adverse effect in the treatment oi patients with chronic pulmonary heart disease, and it's woith to be applied widely in clinical practice.%目的 比较环磷腺苷葡胺联合米力农与洋地黄类强心剂治疗慢性肺心病心力衰竭的疗效与安全性.方法 采用随机、平行对照的研究方法,对108例慢性肺心病心力衰竭随机分成两组:治疗组(54例)在常规治疗的基础上加用环磷腺苷葡胺和米力农;观察组(54例)在常规治疗的基础上加用洋地黄(西地兰针),12天一疗程.结果 治疗组总有效率94.4%,明显优于观察组66.6%(P<0.01),治疗组心功能指标右室内径、右心室流出道/左心房内径及心胸比例的改善明显优于观察组(P<0.01),肺功能、PaO2、PaCO2及脑钠肽改善明显优于观察组(P<0.01),而心率、血压无明显差异(P>0.05);治疗组不良反应主要有心悸、出汗、头痛,减慢静滴速度症状消失,观察组主要不良反应心律失常,常需停药.结论 环磷腺苷葡胺联合米力农治疗慢性肺心病心力衰竭有更好的疗效,更少的副作用,值得临床上进一步推广应用.
展开▼
