IL-21 R、MMP-2在非小细胞肺癌中的表达及相关性研究

摘要

目的：检测白介素-21受体(interleukin-21R,IL-21R)、基质金属蛋白酶-2(matrix metalloprotein-ases-2,MMP-2)在非小细胞肺癌( Non-small-cell lung cancer,NSCLC)癌组织中的表达,并探讨IL-21R、MMP-2的表达在NSCLC发生、发展及浸润转移的影响。方法采用免疫组化法检测50例NSCLC组织及20例正常肺组织对照组中IL-21R、MMP-2的表达,分析其阳性表达率与NSCLC患者临床病理特征的关系,并探讨其相关性。结果 NSCLC癌组织中IL-21R、MMP-2的阳性表达率均显著高于正常肺组织,且两者表达呈负相关(P<0．05)；IL-21R和MMP-2的表达与淋巴结转移、临床分期及组织分化程度相关。结论 NSCLC中MMP-2的表达与其浸润转移正相关,其表达增加表示NSCLC有较高恶性生物学行为；IL-21R的表达与NSCLC浸润转移的呈负相关,且IL-21R、MMP-2在NSCLC发生及浸润过程中具有相关性。%Objective To investigate the expression of interleukin-21 receptor (IL-2R) and matrix metallo-proteinase-2 (MMP-2) in patients with non-small cell lung cancer (NSCLC), and to discuss the influence of the ex-pression of IL-21R and MMP-2 to the disease. Methods The expression of IL-21R and MMP-2 was detected by im-munohistochemical method in 50 patients with non-small cell lung cancer and 20 people with normal lung tissue. The correlation of the positive expression rate of IL-21R and MMP-2 to pathological characteristics was analyzed. Results The positive rate of IL-2R and MMP-2 in NSCLC patients was significantly higher than in the control group, and they were negatively correlated (P<0. 05). The expression of IL-21R and MMP-2 was related to clinical stages, lymph node metastasis status and tissue differentiation degree. Conclusion The expression of MMP-2 in NSCLC pa-tients is positively related with metastasis, which the increased expression shows higher malignant biological behavior in NSCLC patients. The expression of IL-21 R shows a negative correlation with metastasis.