气管肺泡灌洗液基因检测在周围型肺癌中的效果分析

摘要

Objective To understand the effect of trachea pulmonary alveolus lavage fluid gene detection in peripheral lung cancer. Methods 42 patients with peripheral lung cancer were divided into different groups accord-ing to different clinical stages of peripheral lung cancer, and then they were given trachea pulmonary alveolus lavage to detect the expression of trachea pulmonary alveolus lavage fluid gene. Results The results proved that most pe-ripheral lung cancer patients had Survivin gene expression after lavage, which was the highest in 8 patients at stageⅢ(61. 54%) and the lowest in 2 patients at stage Ⅰ (22. 22%). K-ras gene mutation also widespread in peripheral lung cancer patients, but it was different with the expression of Survivin gene. The results of K-ras genic mutation proved that the positive expression of K-ras genic mutation was the highest in 5 patients at stage Ⅰ ( 66. 67%) and the lowest in 2 patients at stage Ⅳ (40%) (P<0. 05). Conclusion The detection of trachea pulmonary alveolus lavage fluid gene has certain value in the diagnosis of peripheral lung cancer.%目的：为了进一步了解气管肺泡灌洗液基因检测在周围型肺癌中的效果,对周围型肺癌患者进行研究分析。方法将2010年12月1日至2014年1月31日期间来我院肿瘤科就诊的42例周围型肺癌的患者作为研究对象,根据患者周围性肺癌的临床阶段不同分为：Ⅰ期Ⅱ期Ⅲ期Ⅳ期,以将每个期的患者作为一组,分别对每组患者进行气管肺泡灌洗,然后检测气管肺泡灌洗液基因在患者体内的表达情况,并对检测结果进行研究分析。结果结果显示,在灌洗后多数周围型肺癌患者都显示有Survivin 基因表达,其中Ⅲ期患者Survivin基因表达阳性率8例(61.54%)最高,Ⅰ期患者Survivin基因表达阳性率2例(22．22%)最低；此外K-ras 基因突变在周围型肺癌患者同样普遍存在,但与Survivin 基因表达情况不太一样,K-ras 基因突变结果Ⅰ期患者 K-ras 基因突变表达阳性率6例(66．67%)最高,Ⅳ期 K-ras 基因突变表达阳性率2例(40．00%)最低,两者比较差异具有统计学意义(P<0．05)。结论气管肺泡灌洗液基因表达对肺癌诊断有一定价值。