N-乙酰半胱氨酸雾化吸入治疗老年AECOPD患者的临床观察

摘要

Objective To observe the clinical efficacy and safety of N-acetylcysteine Inhalation in treatment of elderly patients with AECOPD.Methods 60 patients with AECOPD were randomly divided into two groups.The control group (n=30) received conventional therapy, while the observation group (n=30) received additional NAC inhalation (2/d).Blood gas analysis (PaO2, PaCO2), pulmonary function (FEV1%prd, FEV1/FVC%) and the serum levels of CRP and PCT were evaluated on Day 1 and 14.Results 14 days after treatment, their blood gas analysis, pulmonary function and the serum levels of CRP and PCT all improved (P<0.05), and the improvement was more pronounced in the observation group than in the control group (P<0.05).Conclusion NAC inhalation is an effective and safe method in treatment of elderly patients with AECOPD.%目的 探讨评价在老年慢性阻塞性肺疾病急性加重期(AECOPD)患者中使用N-乙酰半胱氨酸(NAC)雾化吸入治疗的临床疗效.方法 将60例IV级AECOPD患者随机分为观察组和对照组各30例,两组均给予常规治疗,观察组在常规治疗的基础上加用N-乙酰半胱氨酸(NAC)雾化吸入,2次/天.在入院第1天和入院后第14天测定比较两组患者血气分析(PaO2、PaCO2)、肺功能(FEV1%prd、FEV1/FVC%)及血清中CRP、PCT水平.结果 治疗第14天两组患者血气分析(PaO2、PaCO2)、肺功能(FEV1%prd、FEV1/FVC%)及血清中CRP、PCT水平均有好转(P<0.05),且观察组较对照组改善更加明显,差异有统计学意义(P<0.05). 结论 N-乙酰半胱氨酸(NAC)雾化吸入辅助治疗可明显改善老年AECOPD患者的临床症状和肺功能,减轻炎症反应,且安全有效.