Objective:To explore the effects of three interventions:cognitive behavioral therapy,family intervention and vocational rehabilitation intervention on outpatients and their family burden with chronic schizo-phrenia. Method:Two hundred of outpatients with chronic schizophrenia were randomly assigned to the cog-nitive behavioral therapy group,family intervention group,vocational rehabilitation intervention group and the control group. The corresponding treatments were given to the intervention group for one year. All the subjects were evaluated with positive and negative syndrome scale( PANSS ) and family burden scale of diseases ( FBS). Results:The total score and factor scores of PANSS of three intervention groups decreased signifi-cantly after treatment(P<0. 01). The total score and factor scores(family economy,family daily life,family en-tertainment activities,family relationship)of FBS of three intervention groups decreased significantly after treat-ment,and the physical health score of FBS of cognitive behavioral therapy group decreased significantly after treatment(P<0. 05). The difference of family economy score of FBS of Cognitive behavioral therapy group be-tween pre and post treatment increased both in family intervention group and vocational rehabilitation interven-tion group(P<0. 05). Conclusion:Three interventions can significantly alleviate psychiatric symptoms of chronic schizophrenia and improve their family burden.%目的：探讨认知行为治疗、家庭治疗、职业康复3种干预方法对慢性精神分裂症患者及其家庭负担的影响。方法：将慢性精神分裂症患者随机分为干预组（包括认知行为治疗组48例、家庭治疗组46例、职业康复组40例）及对照组44例，在维持原药物治疗基础上进行相应的干预治疗，历时1年。入组时和干预结束采用阳性与阴性症状量表（ PANSS）和家庭负担会谈量表（ FBS）对患者及家属进行评估。结果：干预组干预后PANSS各项评分均低于治疗前（认知行为组：t=3.882~6.697；家庭治疗组：t=4.765~9.608；职业康复组：t=2.956~5.111），与治疗前比较，差异有统计学意义（ P均＜0.01）；FBS总分、经济负担、家庭日常活动、家庭娱乐活动、家庭关系以及认知行为组的躯体健康因子分均低于治疗前（认知行为组：t=2.584~6.086；家庭治疗组：t=2.615~4.906；职业康复组：t=2.438~4.505），与治疗前比较，差异有统计学意义（P＜0.05或P＜0.01）；干预组治疗前后差值方差分析显示，认知行为组的经济负担因子分的差值高于家庭治疗组和职业康复组，差异有统计学意义（ F=3.984，P＜0.05）。
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