2002~2012年间河北省抑郁障碍患者药物使用情况调查

摘要

Objective:To evaluate the use of various antidepressant drugs in depression patients in Hebeiprovince.Method:Eight hundred and thirty four patients with depression in Hebei province within 2002,2006,2012 were coded,and their demographic and antidepressants prescription records were analyzed.Results:The proportion of monoamine oxidase inhibitor(MAOs),tricyclic antidepressants(TCAs),serotonin antidepressants balance(SMA) showed a decreasing with time(P<0.05).The proportion of norepinephrine/selective serotonin receptor agonist(NaSSA) showed a increasing with time(P<0.05).The proportion of serotonin reuptake inhibitors(SSRIs) showed a increasing from 29.1% in 2002 to 64.5% in 2012(P<0.05).The proportion of combined use of two or more kinds of antidepressants drug showed a decreasing with time(P<0.05).The combination of mood stabilizers showed a increasing with time(P<0.05).The combination of benzodiazepine was highest each of the three years.The combination of antipsychotic drugs was in 2002 and 2012 than 2006 and the most combined drugs were atypical antipsychotics.Conclusion:Novel antidepressants are the mainstream to treat patients with depression and have replaced the traditional antidepressants drugs over the past decade.%目的:探讨河北省抑郁障碍患者抗抑郁药使用情况. 方法:调查河北省2002年、2006年及2012年期间834例抑郁障碍患者的处方,对抗抑郁药的使用情况进行统计分析. 结果:3个年份单胺氧化酶抑制剂(MAOs)、三环类抗抑郁药(TCAs)、5-羟色胺(5-HT)平衡抗抑郁药(SMA)处方频率随年份显著下降(P均<0.05);5-HT再摄取抑制剂(SSRIs)、去甲肾上腺素/选择性5-HT受体激动剂(NaSSA)等新型抗抑郁药的使用频率随年份显著增加(P均<0.05);其中SSRIs使用频率从2002年的29.1%增加至2012年的64.5%.合并使用≥2种抗抑郁药频率随年份显著下降(P均<0.05);合并使用心境稳定剂频率随年份显著增加(P<0.05);各年份中合并使用苯二氮艹卓类药的频率均为最高,合并使用抗精神病药频率2002及2012年明显高于2006年,且多为联合非典型抗精神病药. 结论:过去10年间,新型抗抑郁药已成功取代了TCAs等传统抗抑郁药,成为抑郁障碍治疗的主要手段.