新生儿朗格罕斯细胞组织细胞增生症1例报告

摘要

Objective To understand the clinical features and laboratory examination and diagnosis of Langerhas cell histio-cytosis (LCH) in newborns. Methods Retrospective analysis of the clinical data of a neonatal case of LCH was performed. Results A one-day-old girl was admitted with chief complaint of eating less, less crying and skin rash for one day. The unequal sized rash was on the head, limbs, trunk, toe and oral mucosa. The skin rashes were protruding from the skin and were partially broken and crusted. Biopsy of the skin tissue showed the expression of S-100 and CD1α, consistent with the diagnosis of LCH. Conclusions When new-borns have special rash after birth, LCH should be considered. To avoid misdiagnosis, skin biopsy should be performed.%目的：了解新生儿朗格罕斯细胞组织细胞增生症（LCH）的临床、实验室特点及诊断要点。方法回顾性分析1例新生儿LCH的临床资料。结果女性患儿，生后1 d因少吃、少哭，皮疹入院，头部、四肢、躯干、脚趾、口腔可见多发皮疹，突出皮面，大小不等，部分破溃结痂。皮肤活检提示病变组织表达S-100（+），CD1α（+），符合LCH诊断。结论新生儿生后有特殊皮疹，需警惕LCH，应进行皮肤活检，以免误诊。