2型糖尿病患者白内障术后黄斑水肿与房水中TGF-β2、FGF及 MCP-1的研究

摘要

Objective To study the relationship between macular edema and cell factor TGF-beta 2, FGF and MCP-1 in patients with type 2 diabetes after cataract surgery.Methods This study investigated 85 type 2 diabetic patients with cataract that was treated between March 2014 and March 2015.Thirty-nine patients presented macular edema after cat-aract surgery.Retina thickness around macula and cytokine levels (TFG-beta 2, FGF, MCP-1) in these patients were compared to other patients who did not have macular edema.Results Foveal, nasal and temporal retina thickness were significantly higher in patients with macula edema.Higher level of cytokines was also presented in these patients.Analysis showed that levels of TGF-beta 2, FGF, and MCP-1 were all positively correlated to the retina thickness.Conclusions TGF-beta 2, FGF and MCP-1 increased in patients who presented macular edema after surgery.The levels of these cyto-kines were positively correlated to the retina thickness, and therefore can be used as indicators for macular edema.%目的：探讨房水中转化生长因子-β2（TGF-β2）、成纤维细胞生长因子（FGF）及单核细胞趋化因子1（ MCP-1）水平与2型糖尿病患者白内障术后黄斑水肿的联系。方法选取在我院接受手术治疗的85例白内障合并2型糖尿病患者，将术后出现黄斑水肿的39例列为观察组，未出现黄斑水肿的46例作为对照组。对比两组研究对象视网膜厚度；分析两组研究对象房水中细胞因子（ TGF-β2、FGF及MCP-1）水平；分析观察组患者TGF-β2、FGF及MCP-1与视网膜厚度的关系。结果观察组研究对象黄斑区全层视网膜各部位厚度中中心凹、鼻内侧、颞内侧及平均厚度水平显著高于对照组；观察组研究对象TGF-β2、FGF及MCP-1水平明显高于对照组；观察组患者房水中TGF-β2、FGF及MCP-1与视网膜平均厚度值呈正相关。结论房水中TGF-β2、FGF及MCP-1与2型糖尿病患者术后黄斑水肿关系紧密，可作为评价其相关的特异性指标，为临床上预防及减轻黄斑水肿的发生提供有关依据。