S100蛋白在儿童髓母细胞瘤组织中的表达及与预后的关系

摘要

目的 探讨S100蛋白在儿童髓母细胞瘤组织中的表达,分析与肿瘤临床特点之间的关系和对儿童髓母细胞瘤预后的影响.方法 应用免疫组化SP法检测S100蛋白在44例儿童髓母细胞瘤中的表达,并结合长期随访资料进行生存曲线分析.结果 S100阳性表达率为68.18%.S100表达与儿童髓母细胞瘤患者性别、年龄、有无侵犯四脑室、有无坏死之间相关性无统计学意义(P>0.05).19例阳性表达患儿平均生存时间为58.58个月,25例阴性表达患儿平均生存时间为97.1个月.生存曲线分析表明S100的表达与儿童髓母细胞瘤患者生存时间相关.结论 S100蛋白在儿童髓母细胞瘤细胞中表达是患者预后的危险因素.%Objective To explore the expression of S100 in child medulloblastomas ( MB ) and its correlation with clinicopathological characteristics prognosis of children medulloblastomas.Methods SP immunobistochemistry was used to detect the expression of S100 in 44 paraffinembedded child MB specimens. Follow-up data were handled by using Kaplan-Meier survival analysis. Results Positive expression ratio of S100 was 68. 18％ . There was no significant correlation between S100 expression and factors of gender, age, tumor location ( fourth ventricle infiltration) and necrosis ( P ＞ 0. 05 ) . The mean survival time of 19 positive patients was 58. 58 months while that of 25 negative ones was 97. 1 months. Kaplan-Meier survival analysis showed there was significant correlation between expression of S100 and survival time. Conclusion S100may be a valuable factor in the prognosis of children medulloblastomas.