Objective To study whether the cognitive impairment exists in patients with spinocerebellar ataxia type 12 (SCA12), and its influential factors. Methods The cognitive function in 5 SCA12 paitients (SCA12 group) and 13 health controls (normal control group) were examined by Montreal cognitive assessment scale (MoCA) and mini mental state examination scale ( MMSE). The degree of ataxia was assessed by international cooperative ataxia rating scale (ICARS). Results The MoCA score showed that there were 5 cases (100% ) with cognitive impairment in SCA12 group and 10 cases (77% ) with cognitive impairment in normal control group. The MMSE score showed that there were 2 cases (40% ) with cognitive impairment in SCA12 group and 1 case (7.7% ) with cognitive impairment in normal control group. The scores of MoCA and MMSE in SCA12 group were significantly lower than that in the normal control group (all P <0. 05). The score of ICARS in SCA12 group was 23-75, and the average score was (42.6 ±21.0). There was no ataxia in normal control group. Spearmans correlation analysis showed that the score of MMSE was negatively correlated with disease duration of SCA12 patients (r= -0. 894, P = 0.041); the score of abstraction in MoCA was negatively correlated with disease duration of SCA12 patients (r = -0.884,P= 0.047). Conclusion SCA12 patients can complicate with cognitive impairment, which may becorrelated with its long duration of disease.%目的 探讨脊髓小脑共济失凋(SCA)12型患者是否存在认知功能障碍及其影响因素.方法 采用蒙特利尔认知评估量表(MoCA)、简易精神状态检查量表(MMSE)对5例SCA12型患者(SCA12型组)及13名健康体检者(正常对照组)进行认知功能评估；采用国际协作共济失调评估量表(ICARS)进行共济失调严重程度评分.结果 MoCA评分结果显示,SCA12型组存在认知功能障碍5例(100％),正常对照组存在认知功能障碍10例(77％).MMSE评分结果显示,SCA12型组存在认知功能障碍2例(40％),正常对照组存在认知功能障碍1例(7.7％).SCA12型组MoCA和MMSE评分明显低于正常对照组(均P＜0.05).SCA12型组ICARS评分为23 ～ 75分,平均(42.6±21.0)分.正常对照组均无共济失调.Spearmans相关性分析显示,SCA12型患者MMSE评分与病程呈负相关(r=-0.894,P=0.041)；MoCA抽象功能得分与病程呈负相关(r＝-0.884,P =0.047).结论 SCA12型患者可并发认知功能障碍,这可能与其病程较长有关.
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