维持性血液透析患者血清铁蛋白与营养不良-炎症-动脉粥样硬化综合征及贫血的相关性研究

摘要

tein(CRP),IL-6,TNF-αand carotid intima-media thickness were significantly increased in the group with high SF(P <0.05),and the levels of PA,Alb and SGA were significantly reduced.Correlation analysis showed that increased SF levels had positive correlations with CRP(r =0.733,P =0.008), IL-6 (r=0.549,P =0.019),TNF-α(r=0.453,P =0.027)and endometrial thickness of RCCA(r =0.489,P =0.034),and negative correlation with Alb(r=-0.465,P =0.013),PA(r =-0.21 1 ,P=0.042).By treatment with the same dose of EPO for 6 months,Hb in high SF group was signifi-cantly lower than other groups(P <0.01).Conclusions High SF had a negative correlation with nutri-tional status and positive correlation with micro-inflammatory state and atherosclerosis.High SF was independent risk factor of MIA syndrome.It is hard to improve Hb in MHD patients with high SF.%目的探讨终末期肾脏疾病维持性血液透析(maintenance hemodialysis,MHD)患者高水平血清铁蛋白(serum ferritin,SF)与营养不良-炎症-动脉粥样硬化(malnutrition-inflammation-ath-erosclerosis,MIA)综合征及肾性贫血的关系。方法选择2014年6月至2014年12月我院血液净化中心的 MHD 患者共182例,将其中22例 SF 显著升高(SF≥1000μg/L)的 MHD 患者设为高 SF组；选择70例 SF 水平较低(200μg/L