目的 分析缬沙坦联合卡维地洛治疗慢性心力衰竭(CHF)的效果及对血浆脑钠肽(BNP)表达水平的影响.方法将本院收治的79例CHF患者按随机数字表法分为对照组(n=39)与观察组(n=40).对照组给予缬沙坦治疗,观察组给予缬沙坦联合卡维地洛治疗.比较2组患者心功能、BNP表达水平.结果 观察组治疗后心功能改善程度优于对照组;治疗后BNP表达水平低于对照组,差异均有统计学意义(P ＜0.05);2组治疗期间无肝肾异常,不良反应发生率比较无显著差异(P＞ 0.05).结论 缬沙坦联合卡维地洛治疗慢性心力衰竭的治疗效果较为理想,可降低血浆脑钠肽表达水平.%Objective To analyze the effect of valsartan combined with carvedilol intreating chronic heart failure (CHF) and its effect on the expression level of plasma brain natriuretic peptide (BNP). Methods Seventy-nine CHF patients admitted to our hospital were divided into control group (n = 39) and observation group (n = 40) according to the random number table method. The control group was treated with valsartan, while the observation group was treated with valsartan combined with carvedilol. The levels of cardiac function and BNP expression were compared between the two groups. Results The improvement of cardiac function in the observation group was better, and the BNP expression was lower after treatment than that in the control group (P ＜ 0. 05). During the treatment, there was no liver or kidney abnormality between the two groups, and there was no significant difference in the incidence of adverse reactions (P＞ 0. 05). Conclusion Valsartan combined with carvedilol in the treatment of chronic heart failure has an ideal therapeutic effect, which can reduce the level of plasma brain natriuretic peptide expression.
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