含呋喃唑酮的序贯疗法根除儿童幽门螺杆菌的疗效观察

摘要

Objective To observe the efficacy and safety of sequential therapy with Fura zolidone eradication of Helicobacter pylori (Hp). Methods Sixty - six cases of chronic gastritis, gastric and duodenal ulcer children with Hp infection were randomly divided into treatment group (34 cases) and control group (32 cases). The treatment group received Omeprazole + Amoxicillin 5 d before, 2/d, Omeprazole plus Clarithromycin Furazolidone 5d after, 2 times/d. The control group, Omeprazole + Amoxicillin + Clarithromycin, 2 times/d, treated for 7 d. At least 4 weeks after treatment review of 14C- UBT, the efficacy and adverse reactions were assessed. Results Hp eradication rate was 91.2% of the treatment group compared with 78.1 % of the control group. Hp eradication rate was higher than the treatment group (P >0.05). The incidence of adverse reac tions between 2 groups showed no significant difference (P > 0.05). Conclusion Sequential thera py with Furazolidone has higher Hp eradication rate for children, and is more effective than standard triple therapy.%目的 观察含呋喃唑酮的序贯疗法根除儿童幽门螺杆菌(Hp)的疗效及安全性.方法 将66例慢性胃炎及胃、十二指肠溃疡伴Hp感染患儿,随机分为治疗组34例和对照组32例,治疗组前5d予奥美拉唑+阿莫西林,2次/d,后5d予奥美拉唑+克托霉素+呋喃唑酮,2次/d；对照组予奥美拉唑+阿莫西林+克拉霉素,2次/d,疗程7d.疗程结束后至少4周复查14C-UBT,评估疗效及不良反应.结果 治疗组Hp根除率为91.2％,对照组为78.1％.治疗组Hp根除率高于对照组,但差异无统计学意义(P＞0.05).2组不良反应发生率无明显差异(P＞0.05).结论 含呋喃唑酮的序贯疗法对儿童Hp的根除率高,疗效优于标准三联疗法.