Furazolidone‐containing triple and quadruple eradication therapy for initial treatment for        <i >Helicobacter pyloriHelicobacter pylori        infection: A multicenter randomized controlled trial in China

Xie Yong; Zhang Zhenyu; Hong Junbo; Liu Wenzhong; Lu Hong; Du Yiqi; Wang Weihong; Xu Jianming; Wang Xuehong; Huo Lijuan; Zhang Guiying; Lan Chunhui; Li Xiaoyan; Li Yanqing; Wang Hong; Zhang Guoxin; Zhu Yin; Shu Xu; Chen Ye; Wang Jiangbin; Lu Nonghua; the Chinese Society of Gastroenterology Chinese Study Group on

摘要

Abstract <section numbered="no" xml:id="hel12496-sec-0001"> <title type="main">Background > The efficacy of Helicobacter pylori ( H.?pylori ) eradication has steadily declined, primarily because of antibiotic resistance. This study aimed to evaluate the efficacy and safety of furazolidone eradication therapies as initial treatments for H.?pylori infection. </section> <section numbered="no" xml:id="hel12496-sec-0002"> <title type="main">Methods > A national, multicenter, open‐label, randomized controlled trial was performed at 16 sites across 13 provinces in China to evaluate the efficacy and safety of furazolidone‐containing therapies for H.?pylori infection. Treatment na?ve patients were randomly assigned to: esomeprazole 20?mg, bismuth 220?mg, amoxicillin 1000?mg, and furazolidone 100?mg twice daily for 10 and 7?days ( <fc>FAB</fc> 10 and <fc>FAB</fc> 7; the same therapy without bismuth ( <fc>FA</fc> 10 and <fc>FA</fc> 7). The primary and secondary outcomes were the eradication rate and regimen safety, respectively. Treatment success was assessed by the 13 C urea breath test at least 4?weeks after treatment completion. </section> <section numbered="no" xml:id="hel12496-sec-0003"> <title type="main">Results > Overall, according to intention‐to‐treat ( <fc>ITT</fc> ) analysis, the eradication rates for <fc>FAB</fc> 10 and <fc>FAB</fc> 7 were 86.6% (95% confidence interval [ <fc>CI </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“Hel12496-Abs-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <secueeded =“否”XML：ID = “hel12496-sec-0001”> <标题类型=“main”>背景</标题> > 幽门螺杆菌的疗效（ H.?丙棒（ H.? v）根除稳定下降，主要是因为抗生素抗性。本研究旨在评估呋喃唑酮根除疗法的疗效和安全性作为 H.?普罗尼的初始处理感染。 </ p> </ section> <secto numbyed =“no”xml：id =“hel12496-sec-0002”> <标题类型=“main”>方法</ title> >一个国家，多中心，开放 - 标签，随机对照试验在中国的13个省份的16个地点进行，以评估含呋喃酮酮治疗的疗效和安全性的疗法。治疗Na'Ve患者随机分配给：eSomeprazole 20？Mg，铋220？Mg，Amoxicillin 1000？Mg，呋喃唑酮100〜20毫克每日两次，10〜7？天（<Fc> Fab </ Fc> 10和< FC> Fab </ Fc> 7;没有铋的同一疗法（<FC> FA </ FC> 10和<FC> FA </ FC> 7）。主要和二次结果分别是根除率和方案安全性。治疗成功通过 13 / sup> c尿素呼气试验至少4〜2周进行治疗完成后。</ p> </ section> <secteneded =“no”xml：id =“hel12496- sec-0003“> <标题类型=”main“>结果</ title> >总体而言，根据意向治疗（<fc> Itt </ fc>）分析，为<fc> fab的根除率</ Fc> 10和<Fc> Fab </ Fc> 7为86.6％（95％置信区间[<FC> CI </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter 》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b> <span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xie Yong&option=202" target="_blank" rel="nofollow">Xie Yong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Zhenyu&option=202" target="_blank" rel="nofollow">Zhang Zhenyu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hong Junbo&option=202" target="_blank" rel="nofollow">Hong Junbo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Wenzhong&option=202" target="_blank" rel="nofollow">Liu Wenzhong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lu Hong&option=202" target="_blank" rel="nofollow">Lu Hong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Du Yiqi&option=202" target="_blank" rel="nofollow">Du Yiqi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Weihong&option=202" target="_blank" rel="nofollow">Wang Weihong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xu Jianming&option=202" target="_blank" rel="nofollow">Xu Jianming;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Xuehong&option=202" target="_blank" rel="nofollow">Wang Xuehong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Huo Lijuan&option=202" target="_blank" rel="nofollow">Huo Lijuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Guiying&option=202" target="_blank" rel="nofollow">Zhang Guiying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lan Chunhui&option=202" target="_blank" rel="nofollow">Lan Chunhui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Xiaoyan&option=202" target="_blank" rel="nofollow">Li Xiaoyan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Yanqing&option=202" target="_blank" rel="nofollow">Li Yanqing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Hong&option=202" target="_blank" rel="nofollow">Wang Hong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Guoxin&option=202" target="_blank" rel="nofollow">Zhang Guoxin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhu Yin&option=202" target="_blank" rel="nofollow">Zhu Yin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shu Xu&option=202" target="_blank" rel="nofollow">Shu Xu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Ye&option=202" target="_blank" rel="nofollow">Chen Ye;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Jiangbin&option=202" target="_blank" rel="nofollow">Wang Jiangbin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lu Nonghua&option=202" target="_blank" rel="nofollow">Lu Nonghua;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=the Chinese Society of Gastroenterology Chinese Study Group on&option=202" target="_blank" rel="nofollow">the Chinese Society of Gastroenterology Chinese Study Group on;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of GastroenterologyFirst Affiliated Hospital of Nanchang UniversityJiangxi China;</p> <p>Department of GastroenterologyNanjing First HospitalJiangsu China;</p> <p>Department of GastroenterologyFirst Affiliated Hospital of Nanchang UniversityJiangxi China;</p> <p>Department of GastroenterologyShanghai Jiao Tong University School of MedicineShanghai China;</p> <p>Department of GastroenterologyShanghai Jiao Tong University School of MedicineShanghai China;</p> <p>Department of GastroenterologySecond Military Medical UniversityShanghai China;</p> <p>Department of GastroenterologyPeking University First HospitalBeijing China;</p> <p>Department of GastroenterologyThe First Affiliated Hospital of Anhui Medical UniversityAnhui China;</p> <p>Department of GastroenterologyQinghai University Affiliated HospitalQinghai China;</p> <p>Department of GastroenterologyFirst Hospital of Shanxi Medical UniversityShanxi China;</p> <p>Department of GastroenterologyXiangya Hospital of Central South UniversityHunan China;</p> <p>Department of GastroenterologyDaping Hospital and the Research Institute of Surgery of Third Military Medical UniversityChongqing China;</p> <p>Department of GastroenterologyFirst Affiliated Hospital of Kunming Medical CollegeYunnan China;</p> <p>Department of GastroenterologyQilu Hospital of Shandong UniversityShandong China;</p> <p>Department of GastroenterologyGuangzhou First People's HospitalGuangdong China;</p> <p>Department of GastroenterologyJiangsu Province HospitalJiangsu China;</p> <p>Department of GastroenterologyFirst Affiliated Hospital of Nanchang UniversityJiangxi China;</p> <p>Department of GastroenterologyFirst Affiliated Hospital of Nanchang UniversityJiangxi China;</p> <p>Department of GastroenterologySouthern Medical UniversityGuangzhou China;</p> <p>Department of GastroenterologyChina‐Japan Union Hospital of Jilin UniversityChangchun Jilin China;</p> <p>Department of GastroenterologyFirst Affiliated Hospital of Nanchang UniversityJiangxi China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=furazolidone&option=203" rel="nofollow">furazolidone;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Helicobacter pylori&option=203" rel="nofollow">Helicobacter pylori;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=quadruple therapy&option=203" rel="nofollow">quadruple therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=triple therapy&option=203" rel="nofollow">triple therapy;</a> </p> <div class="translation"> 机译：呋喃唑酮;幽门螺杆菌;四重治疗;三重治疗; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" 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href="/academic-journal-foreign-pmc_detail_thesis/040005214560.html">Modified quadruple therapy versus bismuth-containing quadruple therapy in first-line treatment of Helicobacter pylori infection in Korea; rationale and design of an open-label multicenter randomized controlled trial</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hyun Lim&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hyun Lim,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chang Seok Bang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chang Seok Bang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Woon Geon Shin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Woon Geon Shin,</a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：韩国一线治疗幽门螺杆菌感染的改良四联疗法与含铋四联疗法；开放性多中心随机对照试验的原理和设计</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000125179686.html">Modified quadruple therapy versus bismuth-containing quadruple therapy in first-line treatment of Helicobacter pylori infection in Korea; rationale and design of an open-label, multicenter, randomized controlled trial</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hyun Lim&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hyun Lim,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chang Seok Bang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chang Seok Bang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Woon Geon Shin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Woon Geon Shin,</a> <span>2018</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：改良的四重治疗与含有铋的四重疗法在韩国幽门螺杆菌感染的一线治疗中;开放标签，多中心，随机对照试验的理由和设计</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_strait-pharmaceutical-journal_thesis/0201240507550.html">含呋喃唑酮三、四联疗法根除幽门螺杆菌感染的临床观察</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈义辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈义辉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蔡和利&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,蔡和利</a> <span> <a href="/journal-cn-6383/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 海峡药学 </a> </span> <span> . 2015</span><span> ,第012期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-gastroenterology_thesis/0201250596296.html">10d含呋喃唑酮三联、四联疗法补救治疗幽门螺杆菌感染的比较研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄海辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 黄海辉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈德强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈德强</a> <span> <a href="/journal-cn-15008/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 胃肠病学 </a> </span> <span> . 2014</span><span> ,第006期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-medicine_thesis/0201254009467.html">含呋喃唑酮的三联疗法治疗儿童幽门螺杆菌感染</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张艳玲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张艳玲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=贾立英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,贾立英</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=徐辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,徐辉</a> <span> <a href="/journal-cn-6701/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国医刊 </a> </span> <span> . 2008</span><span> ,第001期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-gastroenterology-hepatology_thesis/0201250721147.html">含呋喃唑酮短程三联及四联药物治疗幽门螺杆菌感染成本效果分析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=龚飞跃&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 龚飞跃</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙达春&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,孙达春</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈剑鸣&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈剑鸣</a> <span> <a href="/journal-cn-15009/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 胃肠病学和肝病学杂志 </a> </span> <span> . 2002</span><span> ,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_jilin-medical-journal_thesis/0201249046320.html">雷贝拉唑、呋喃唑酮、加替沙星三联疗法根除幽门螺杆菌感染的疗效观察</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=董新锋&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 董新锋</a> <span> <a href="/journal-cn-6629/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 吉林医学 </a> </span> <span> . 2010</span><span> ,第006期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-40760_thesis/020222451447.html">序贯疗法与含呋喃唑酮三联疗法对根除幽门螺杆菌的疗效及安全性分析</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王磊&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王磊</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=高鸿亮&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,高鸿亮</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=姚萍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,姚萍</a> <span> <a href="/conference-cn-40760/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2015慢性病健康管理高峰论坛暨新疆医学会健康管理学专业委员会健康管理学术年会 </a> <span> <span> . 2015</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311456142.html">含呋喃唑酮三联疗法根除儿童幽门螺杆菌感染的临床研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=罗纯奇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 罗纯奇</a> <span> . 2018</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120100095100.html">过氧化氢在制备幽门螺杆菌感染根除治疗药物中的应用及制备的药物</a> <b>[P]</b> . <span> 中国专利： CN109223825A </span> <span> . 2019-01-18</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120100039113.html">高锰酸钾在制备幽门螺杆菌感染根除治疗药物中的应用及制备的药物</a> <b>[P]</b> . <span> 中国专利： CN109288861A </span> <span> . 2019-02-01</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130449100227.html">Compound, process for the preparation of it, pharmaceutical formulation, use of the compound, processes to inhibit gastric acid secretion, for the treatment of inflammatory gastrointestinal diseases, and for the treatment or prophylaxis of conditions involving helicobacter pylori infection of the mucosa human gastric, and, pharmaceutical formulations for use in inhibiting gastric acid secretion, for use in the treatment of inflammatory gastrointestinal diseases, and for use in the treatment or prophylaxis of conditions involving helicobacter pylori infection of the human gastric mucosa</a> <b>[P]</b> . <span> 外国专利：  BR9913103A </span> <span> . 2001-05-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：该化合物，其制备方法，药物制剂，该化合物的使用，抑制胃酸分泌的方法，用于治疗炎性胃肠疾病以及用于治疗或预防人胃黏膜幽门螺杆菌感染的疾病的方法，以及用于抑制胃酸分泌，用于治疗炎性胃肠疾病以及用于治疗或预防涉及人胃粘膜的幽门螺杆菌感染的疾病的药物制剂 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130440128571.html">Imidazole composition, method for production thereof, pharmaceutical composition, commercial packaging, method for the prophylaxis or treatment of diseases, method for eradicating helicobacter pylori from a helicobacter pylori infected animal, and use of a compound</a> <b>[P]</b> . <span> 外国专利：  BR0311801A </span> <span> . 2005-04-12</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：咪唑组合物，其制备方法，药物组合物，商业包装，疾病预防或治疗方法，从幽门螺杆菌感染的动物中根除幽门螺杆菌的方法以及化合物的用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130452668506.html">‡ nucleic acid, nucleic acid molecule, probe, recombinant expression vector, cell, processes to produce a h polypeptide. pylori and to detect the presence of a helicobacter pylori nucleic acid in a sample, h. pylori isolated, cell, cellular and secreted envelope polypeptides from h. pylori or its fragments, fusion protein, vaccine formulation for the prophylaxis or treatment of an infection by h. pylori, and, processes to treat or reduce a risk of infection by h. pylori in a subject and to produce a vaccine formulation.</a> <b>[P]</b> . <span> 外国专利：  BR9712587A </span> <span> . 1999-10-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：‡核酸，核酸分子，探针，重组表达载体，细胞，产生h多肽的过程。并检测样品中是否存在幽门螺杆菌核酸; h。来自h的幽门螺杆菌分离的，细胞，细胞和分泌的包膜多肽幽门螺杆菌或其片段，融合蛋白，疫苗制剂，用于预防或治疗h感染。幽门螺杆菌，以及治疗或降低h感染风险的方法。幽门螺杆菌在受试者体内并产生疫苗制剂。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025099318','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" 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Furazolidone‐containing triple and quadruple eradication therapy for initial treatment for Helicobacter pyloriHelicobacter pylori infection: A multicenter randomized controlled trial in China

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